The activity of caspase-3-like proteases is elevated during the development of colorectal carcinoma

L. Leonardos, L. M. Butler, P. J. Hewett, P. D. Zalewski, P. A. Cowled

Research output: Contribution to journalArticlepeer-review

19 Citations (Scopus)

Abstract

Activated caspase-3-like proteases promote apoptotic cell death by cleaving cellular substrates. Caspase-3-like activity was measured in colonic carcinomas and in matched normal colonic mucosa from 31 patients and was significantly elevated in 25/31 colonic carcinomas and adenomas when compared to normal mucosa (P<0.0001). Caspase-3-like activity was much higher in normal mucosa and tumours of female subjects than of males (P<0.0001). No correlation was obtained between caspase-3-like activity and location of the tumour, tumour grade, stage, or patient age. The marked increase in caspase-3-like activity in colorectal carcinomas may reflect an increase in the proportion of cells undergoing spontaneous apoptosis. Copyright (C) 1999 Elsevier Science Ireland Ltd.

Original languageEnglish
Pages (from-to)29-35
Number of pages7
JournalCancer Letters
Volume143
Issue number1
DOIs
Publication statusPublished or Issued - 23 Aug 1999
Externally publishedYes

Keywords

  • Apoptosis
  • Caspase-3
  • Colorectal carcinoma
  • Fluorescence
  • Protease

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

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