Th2 cells in health and disease

Toshinori Nakayama, Kiyoshi Hirahara, Atsushi Onodera, Yusuke Endo, Hiroyuki Hosokawa, Kenta Shinoda, Damon J. Tumes, Yoshitaka Okamoto

Research output: Contribution to journalReview article

87 Citations (Scopus)

Abstract

Helper T (Th) cell subsets direct immune responses by producing signature cytokines. Th2 cells produce IL-4, IL-5, and IL-13, which are important in humoral immunity and protection from helminth infection and are central to the pathogenesis of many allergic inflammatory diseases. Molecular analysis of Th2 cell differentiation and maintenance of function has led to recent discoveries that have refined our understanding of Th2 cell biology. Epigenetic regulation of Gata3 expression by chromatin remodeling complexes such as Polycomb and Trithorax is crucial for maintaining Th2 cell identity. In the context of allergic diseases, memory-type pathogenic Th2 cells have been identified in both mice and humans. To better understand these disease-driving cell populations, we have developed a model called the pathogenic Th population disease induction model. The concept of defined subsets of pathogenic Th cells may spur new, effective strategies for treating intractable chronic inflammatory disorders.

Original languageEnglish
Pages (from-to)53-84
Number of pages32
JournalAnnual Review of Immunology
Volume35
DOIs
Publication statusPublished - 26 Apr 2017

Keywords

  • Allergy
  • Epigenetics
  • Gata3
  • Pathogenic Th2 cell
  • Polycomb
  • Th2
  • Trithorax

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology

Cite this

Nakayama, T., Hirahara, K., Onodera, A., Endo, Y., Hosokawa, H., Shinoda, K., ... Okamoto, Y. (2017). Th2 cells in health and disease. Annual Review of Immunology, 35, 53-84. https://doi.org/10.1146/annurev-immunol-051116-052350