Temporal evolution of left ventricular dyssynchrony after myocardial infarction: Relation with changes in left ventricular systolic function

Gaetano Nucifora, Matteo Bertini, Nina Ajmone Marsan, Arthur J. Scholte, Hans Marc J. Siebelink, Eduard R. Holman, Martin J. Schalij, Ernst E. Van Der Wall, Jeroen J. Bax, Victoria Delgado

Research output: Contribution to journalArticle

7 Citations (Scopus)

Abstract

Aims: The relationship between temporal changes in left ventricular (LV) dyssynchrony and LV functional recovery after acute myocardial infarction (MI) remains unclear. Accordingly, the aim of the present study was to evaluate the temporal evolution of LV synchronicity after acute MI, and to explore the relationship between changes in LV systolic function and LV synchronicity. Methods and resultsIn 193 patients with a first acute MI, LV dyssynchrony (SDI) and global systolic function were evaluated with real-time three-dimensional echocardiography 48 h after percutaneous coronary intervention and at 6 months follow-up. Changes in LV systolic function and synchronicity were evaluated at the follow-up and the relationship between these changes was explored. A total of 59 (40) patients had an anterior acute MI. Median peak value of troponin T was 2.97 g/L (1.41-6.06 g/L). Mean LVEF was 47 ± 8 and mean SDI was 5.01 ± 2.10, respectively. At 6 months follow-up, a significant improvement in LVEF (50 ± 9 vs. 47 ± 8; P < 0.001) and SDI (4.52 ± 1.97 vs. 5.01 ± 2.10; P 0.003) was noted. A strong correlation was found between LVEF change and SDI change (β-0.63; P < 0.001). At multivariate analysis, SDI change was an independent factor associated with changes in LVEF. Importantly, an addition of SDI change to the multivariate model significantly increased the R2 from 0.41 to 0.57 (F change 49.0, P < 0.001).ConclusionA temporal evolution of LV synchronicity was observed after a first, mechanically reperfused, acute MI. The reduction in LV dyssynchrony independently influenced LV functional recovery in these patients.

LanguageEnglish
Pages1041-1046
Number of pages6
JournalEuropean heart journal cardiovascular Imaging
Volume13
Issue number12
DOIs
Publication statusPublished - Dec 2012

Keywords

  • Acute myocardial infarction
  • LV dyssynchrony
  • Real-time 3-dimensional echocardiography

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging
  • Cardiology and Cardiovascular Medicine

Cite this

Nucifora, Gaetano ; Bertini, Matteo ; Ajmone Marsan, Nina ; Scholte, Arthur J. ; Siebelink, Hans Marc J. ; Holman, Eduard R. ; Schalij, Martin J. ; Van Der Wall, Ernst E. ; Bax, Jeroen J. ; Delgado, Victoria. / Temporal evolution of left ventricular dyssynchrony after myocardial infarction : Relation with changes in left ventricular systolic function. In: European heart journal cardiovascular Imaging. 2012 ; Vol. 13, No. 12. pp. 1041-1046.
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title = "Temporal evolution of left ventricular dyssynchrony after myocardial infarction: Relation with changes in left ventricular systolic function",
abstract = "Aims: The relationship between temporal changes in left ventricular (LV) dyssynchrony and LV functional recovery after acute myocardial infarction (MI) remains unclear. Accordingly, the aim of the present study was to evaluate the temporal evolution of LV synchronicity after acute MI, and to explore the relationship between changes in LV systolic function and LV synchronicity. Methods and resultsIn 193 patients with a first acute MI, LV dyssynchrony (SDI) and global systolic function were evaluated with real-time three-dimensional echocardiography 48 h after percutaneous coronary intervention and at 6 months follow-up. Changes in LV systolic function and synchronicity were evaluated at the follow-up and the relationship between these changes was explored. A total of 59 (40) patients had an anterior acute MI. Median peak value of troponin T was 2.97 g/L (1.41-6.06 g/L). Mean LVEF was 47 ± 8 and mean SDI was 5.01 ± 2.10, respectively. At 6 months follow-up, a significant improvement in LVEF (50 ± 9 vs. 47 ± 8; P < 0.001) and SDI (4.52 ± 1.97 vs. 5.01 ± 2.10; P 0.003) was noted. A strong correlation was found between LVEF change and SDI change (β-0.63; P < 0.001). At multivariate analysis, SDI change was an independent factor associated with changes in LVEF. Importantly, an addition of SDI change to the multivariate model significantly increased the R2 from 0.41 to 0.57 (F change 49.0, P < 0.001).ConclusionA temporal evolution of LV synchronicity was observed after a first, mechanically reperfused, acute MI. The reduction in LV dyssynchrony independently influenced LV functional recovery in these patients.",
keywords = "Acute myocardial infarction, LV dyssynchrony, Real-time 3-dimensional echocardiography",
author = "Gaetano Nucifora and Matteo Bertini and {Ajmone Marsan}, Nina and Scholte, {Arthur J.} and Siebelink, {Hans Marc J.} and Holman, {Eduard R.} and Schalij, {Martin J.} and {Van Der Wall}, {Ernst E.} and Bax, {Jeroen J.} and Victoria Delgado",
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Nucifora, G, Bertini, M, Ajmone Marsan, N, Scholte, AJ, Siebelink, HMJ, Holman, ER, Schalij, MJ, Van Der Wall, EE, Bax, JJ & Delgado, V 2012, 'Temporal evolution of left ventricular dyssynchrony after myocardial infarction: Relation with changes in left ventricular systolic function', European heart journal cardiovascular Imaging, vol. 13, no. 12, pp. 1041-1046. https://doi.org/10.1093/ehjci/jes095

Temporal evolution of left ventricular dyssynchrony after myocardial infarction : Relation with changes in left ventricular systolic function. / Nucifora, Gaetano; Bertini, Matteo; Ajmone Marsan, Nina; Scholte, Arthur J.; Siebelink, Hans Marc J.; Holman, Eduard R.; Schalij, Martin J.; Van Der Wall, Ernst E.; Bax, Jeroen J.; Delgado, Victoria.

In: European heart journal cardiovascular Imaging, Vol. 13, No. 12, 12.2012, p. 1041-1046.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Temporal evolution of left ventricular dyssynchrony after myocardial infarction

T2 - European heart journal cardiovascular Imaging

AU - Nucifora, Gaetano

AU - Bertini, Matteo

AU - Ajmone Marsan, Nina

AU - Scholte, Arthur J.

AU - Siebelink, Hans Marc J.

AU - Holman, Eduard R.

AU - Schalij, Martin J.

AU - Van Der Wall, Ernst E.

AU - Bax, Jeroen J.

AU - Delgado, Victoria

PY - 2012/12

Y1 - 2012/12

N2 - Aims: The relationship between temporal changes in left ventricular (LV) dyssynchrony and LV functional recovery after acute myocardial infarction (MI) remains unclear. Accordingly, the aim of the present study was to evaluate the temporal evolution of LV synchronicity after acute MI, and to explore the relationship between changes in LV systolic function and LV synchronicity. Methods and resultsIn 193 patients with a first acute MI, LV dyssynchrony (SDI) and global systolic function were evaluated with real-time three-dimensional echocardiography 48 h after percutaneous coronary intervention and at 6 months follow-up. Changes in LV systolic function and synchronicity were evaluated at the follow-up and the relationship between these changes was explored. A total of 59 (40) patients had an anterior acute MI. Median peak value of troponin T was 2.97 g/L (1.41-6.06 g/L). Mean LVEF was 47 ± 8 and mean SDI was 5.01 ± 2.10, respectively. At 6 months follow-up, a significant improvement in LVEF (50 ± 9 vs. 47 ± 8; P < 0.001) and SDI (4.52 ± 1.97 vs. 5.01 ± 2.10; P 0.003) was noted. A strong correlation was found between LVEF change and SDI change (β-0.63; P < 0.001). At multivariate analysis, SDI change was an independent factor associated with changes in LVEF. Importantly, an addition of SDI change to the multivariate model significantly increased the R2 from 0.41 to 0.57 (F change 49.0, P < 0.001).ConclusionA temporal evolution of LV synchronicity was observed after a first, mechanically reperfused, acute MI. The reduction in LV dyssynchrony independently influenced LV functional recovery in these patients.

AB - Aims: The relationship between temporal changes in left ventricular (LV) dyssynchrony and LV functional recovery after acute myocardial infarction (MI) remains unclear. Accordingly, the aim of the present study was to evaluate the temporal evolution of LV synchronicity after acute MI, and to explore the relationship between changes in LV systolic function and LV synchronicity. Methods and resultsIn 193 patients with a first acute MI, LV dyssynchrony (SDI) and global systolic function were evaluated with real-time three-dimensional echocardiography 48 h after percutaneous coronary intervention and at 6 months follow-up. Changes in LV systolic function and synchronicity were evaluated at the follow-up and the relationship between these changes was explored. A total of 59 (40) patients had an anterior acute MI. Median peak value of troponin T was 2.97 g/L (1.41-6.06 g/L). Mean LVEF was 47 ± 8 and mean SDI was 5.01 ± 2.10, respectively. At 6 months follow-up, a significant improvement in LVEF (50 ± 9 vs. 47 ± 8; P < 0.001) and SDI (4.52 ± 1.97 vs. 5.01 ± 2.10; P 0.003) was noted. A strong correlation was found between LVEF change and SDI change (β-0.63; P < 0.001). At multivariate analysis, SDI change was an independent factor associated with changes in LVEF. Importantly, an addition of SDI change to the multivariate model significantly increased the R2 from 0.41 to 0.57 (F change 49.0, P < 0.001).ConclusionA temporal evolution of LV synchronicity was observed after a first, mechanically reperfused, acute MI. The reduction in LV dyssynchrony independently influenced LV functional recovery in these patients.

KW - Acute myocardial infarction

KW - LV dyssynchrony

KW - Real-time 3-dimensional echocardiography

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