Temporal changes in blood product usage in preterm neonates born at less than 30 weeks' gestation in Canada

Amy K. Keir, Junmin Yang, Adele Harrison, Ermelinda Pelausa, Prakesh S. Shah, Canadian Neonatal Network

Research output: Contribution to journalArticle

20 Citations (Scopus)

Abstract

BACKGROUND: Knowledge of neonatal transfusion practices remains limited to local cohorts or survey-based studies. This study evaluated the pattern and temporal changes in the types and frequency of blood product use among preterm neonates born at less than 30 weeks' gestation in Canada. STUDY DESIGN AND METHODS: A retrospective cohort study of preterm neonates born at less than 30 weeks' gestation and admitted to participating neonatal intensive care units in the Canadian Neonatal Network from 2004 to 2012 was conducted to evaluate blood product usage. The temporal change in red blood cell (RBC) use was evaluated by dividing the study period into three epochs: 2004 to 2006, 2007 to 2009, and 2010 to 2012. RESULTS: Of 14,868 eligible neonates admitted to participating units in Canada during the overall study period, 8252 (56%) received RBCs, 2151 (15%) platelets, 1556 (11%) fresh-frozen plasma, 915 (6%) albumin, and 302 (2%) cryoprecipitate. Temporal evaluation over three epochs revealed a trend toward fewer RBC transfusions among neonates born at 26 to 29 weeks' gestation (p = <0.01-0.04) but use remained unchanged or increased for neonates born at 23 to 25 weeks' gestation (p = 0.02-0.54). CONCLUSION: Blood product use remains at a very high frequency in preterm neonates born at less than 30 weeks' gestation. Evolutionary practice changes and relative high tolerance for anemia may be associated with a reduction in RBC usage in recent years in neonates born at at least 26 weeks' gestation. This contrasts with the ongoing higher usage of blood products observed at extremely low gestational ages.

LanguageEnglish
Pages1340-1346
Number of pages7
JournalTransfusion
Volume55
Issue number6
DOIs
Publication statusPublished - 1 Jun 2015
Externally publishedYes

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology
  • Hematology

Cite this

Keir, A. K., Yang, J., Harrison, A., Pelausa, E., Shah, P. S., & Canadian Neonatal Network (2015). Temporal changes in blood product usage in preterm neonates born at less than 30 weeks' gestation in Canada. Transfusion, 55(6), 1340-1346. https://doi.org/10.1111/trf.12998
Keir, Amy K. ; Yang, Junmin ; Harrison, Adele ; Pelausa, Ermelinda ; Shah, Prakesh S. ; Canadian Neonatal Network. / Temporal changes in blood product usage in preterm neonates born at less than 30 weeks' gestation in Canada. In: Transfusion. 2015 ; Vol. 55, No. 6. pp. 1340-1346.
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abstract = "BACKGROUND: Knowledge of neonatal transfusion practices remains limited to local cohorts or survey-based studies. This study evaluated the pattern and temporal changes in the types and frequency of blood product use among preterm neonates born at less than 30 weeks' gestation in Canada. STUDY DESIGN AND METHODS: A retrospective cohort study of preterm neonates born at less than 30 weeks' gestation and admitted to participating neonatal intensive care units in the Canadian Neonatal Network from 2004 to 2012 was conducted to evaluate blood product usage. The temporal change in red blood cell (RBC) use was evaluated by dividing the study period into three epochs: 2004 to 2006, 2007 to 2009, and 2010 to 2012. RESULTS: Of 14,868 eligible neonates admitted to participating units in Canada during the overall study period, 8252 (56{\%}) received RBCs, 2151 (15{\%}) platelets, 1556 (11{\%}) fresh-frozen plasma, 915 (6{\%}) albumin, and 302 (2{\%}) cryoprecipitate. Temporal evaluation over three epochs revealed a trend toward fewer RBC transfusions among neonates born at 26 to 29 weeks' gestation (p = <0.01-0.04) but use remained unchanged or increased for neonates born at 23 to 25 weeks' gestation (p = 0.02-0.54). CONCLUSION: Blood product use remains at a very high frequency in preterm neonates born at less than 30 weeks' gestation. Evolutionary practice changes and relative high tolerance for anemia may be associated with a reduction in RBC usage in recent years in neonates born at at least 26 weeks' gestation. This contrasts with the ongoing higher usage of blood products observed at extremely low gestational ages.",
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Keir, AK, Yang, J, Harrison, A, Pelausa, E, Shah, PS & Canadian Neonatal Network 2015, 'Temporal changes in blood product usage in preterm neonates born at less than 30 weeks' gestation in Canada', Transfusion, vol. 55, no. 6, pp. 1340-1346. https://doi.org/10.1111/trf.12998

Temporal changes in blood product usage in preterm neonates born at less than 30 weeks' gestation in Canada. / Keir, Amy K.; Yang, Junmin; Harrison, Adele; Pelausa, Ermelinda; Shah, Prakesh S.; Canadian Neonatal Network.

In: Transfusion, Vol. 55, No. 6, 01.06.2015, p. 1340-1346.

Research output: Contribution to journalArticle

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T1 - Temporal changes in blood product usage in preterm neonates born at less than 30 weeks' gestation in Canada

AU - Keir, Amy K.

AU - Yang, Junmin

AU - Harrison, Adele

AU - Pelausa, Ermelinda

AU - Shah, Prakesh S.

AU - Canadian Neonatal Network

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Y1 - 2015/6/1

N2 - BACKGROUND: Knowledge of neonatal transfusion practices remains limited to local cohorts or survey-based studies. This study evaluated the pattern and temporal changes in the types and frequency of blood product use among preterm neonates born at less than 30 weeks' gestation in Canada. STUDY DESIGN AND METHODS: A retrospective cohort study of preterm neonates born at less than 30 weeks' gestation and admitted to participating neonatal intensive care units in the Canadian Neonatal Network from 2004 to 2012 was conducted to evaluate blood product usage. The temporal change in red blood cell (RBC) use was evaluated by dividing the study period into three epochs: 2004 to 2006, 2007 to 2009, and 2010 to 2012. RESULTS: Of 14,868 eligible neonates admitted to participating units in Canada during the overall study period, 8252 (56%) received RBCs, 2151 (15%) platelets, 1556 (11%) fresh-frozen plasma, 915 (6%) albumin, and 302 (2%) cryoprecipitate. Temporal evaluation over three epochs revealed a trend toward fewer RBC transfusions among neonates born at 26 to 29 weeks' gestation (p = <0.01-0.04) but use remained unchanged or increased for neonates born at 23 to 25 weeks' gestation (p = 0.02-0.54). CONCLUSION: Blood product use remains at a very high frequency in preterm neonates born at less than 30 weeks' gestation. Evolutionary practice changes and relative high tolerance for anemia may be associated with a reduction in RBC usage in recent years in neonates born at at least 26 weeks' gestation. This contrasts with the ongoing higher usage of blood products observed at extremely low gestational ages.

AB - BACKGROUND: Knowledge of neonatal transfusion practices remains limited to local cohorts or survey-based studies. This study evaluated the pattern and temporal changes in the types and frequency of blood product use among preterm neonates born at less than 30 weeks' gestation in Canada. STUDY DESIGN AND METHODS: A retrospective cohort study of preterm neonates born at less than 30 weeks' gestation and admitted to participating neonatal intensive care units in the Canadian Neonatal Network from 2004 to 2012 was conducted to evaluate blood product usage. The temporal change in red blood cell (RBC) use was evaluated by dividing the study period into three epochs: 2004 to 2006, 2007 to 2009, and 2010 to 2012. RESULTS: Of 14,868 eligible neonates admitted to participating units in Canada during the overall study period, 8252 (56%) received RBCs, 2151 (15%) platelets, 1556 (11%) fresh-frozen plasma, 915 (6%) albumin, and 302 (2%) cryoprecipitate. Temporal evaluation over three epochs revealed a trend toward fewer RBC transfusions among neonates born at 26 to 29 weeks' gestation (p = <0.01-0.04) but use remained unchanged or increased for neonates born at 23 to 25 weeks' gestation (p = 0.02-0.54). CONCLUSION: Blood product use remains at a very high frequency in preterm neonates born at less than 30 weeks' gestation. Evolutionary practice changes and relative high tolerance for anemia may be associated with a reduction in RBC usage in recent years in neonates born at at least 26 weeks' gestation. This contrasts with the ongoing higher usage of blood products observed at extremely low gestational ages.

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JO - Transfusion

T2 - Transfusion

JF - Transfusion

SN - 0041-1132

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Keir AK, Yang J, Harrison A, Pelausa E, Shah PS, Canadian Neonatal Network. Temporal changes in blood product usage in preterm neonates born at less than 30 weeks' gestation in Canada. Transfusion. 2015 Jun 1;55(6):1340-1346. https://doi.org/10.1111/trf.12998