Targeted Deletion of an Entire Chromosome Using CRISPR/Cas9

Fatwa Adikusuma, Nicole Williams, Frank Grutzner, James Hughes, Paul Thomas

Research output: Contribution to journalLetterpeer-review

31 Citations (Scopus)

Abstract

CRISPR/Cas9 genome editing can facilitate efficient deletion of genomic region, but it has not been used to delete an entire chromosome. Here, Adikusuma et al. show proof-of-concept for efficient CRISPR-mediated selective chromosome deletion by removing the centromere or shredding the chromosome arm in mouse embryonic stem cells and zygotes.

Original languageEnglish
Pages (from-to)1736-1738
Number of pages3
JournalMolecular Therapy
Volume25
Issue number8
DOIs
Publication statusPublished or Issued - 2 Aug 2017

ASJC Scopus subject areas

  • Molecular Medicine
  • Molecular Biology
  • Genetics
  • Pharmacology
  • Drug Discovery

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