Systematic review and metaanalysis on nonclassic cardiovascular biomarkers after hypertensive pregnancy disorders

Sanne Visser, Wietske Hermes, Johannes C F Ket, René H J Otten, Maria G. van Pampus, Kitty W M Bloemenkamp, Arie Franx, Ben W. Mol, Christianne J M de Groot

Research output: Contribution to journalArticle

20 Citations (Scopus)

Abstract

Objective The aim of this study was to investigate which nonclassic cardiovascular biomarkers are associated with persistent endothelial dysfunction after pregnancy in women with a history of hypertensive pregnancy disorders compared with women with uncomplicated pregnancies. Study Design This was a systematic review and metaanalysis of observational studies. A search was performed in PubMed, Embase, Cochrane, and Cinahl including articles from inception to Feb. 27, 2013. Included were cohort studies and case-control studies. Cases were women with a history of hypertension in pregnancy, control subjects were women with a history of uncomplicated pregnancies. Of the 3136 found, 21 studies on 16 nonclassic cardiovascular biomarkers are described in this review; 12 studies on 5 biomarkers were included in the metaanalysis.

Results Women with a history of hypertensive pregnancy disorders had a higher homocysteine level compared with women with a history of uncomplicated pregnancies (5 studies; pooled mean difference, 0.77 ng/mL; 95% confidence interval, 0.27-1.26; P <.01). For the other nonclassic cardiovascular biomarkers including markers in areas of inflammation, thrombosis, and angiogenesis, we found no significant differences.

Conclusion This review and metaanalysis showed that women with a history of hypertensive pregnancy disorders have higher homocysteine levels compared with women with a history of uncomplicated pregnancies. These data suggest persistent endothelial alteration after pregnancies complicated by hypertensive disorders.

LanguageEnglish
Pages373.e1-373.e9
JournalAmerican Journal of Obstetrics and Gynecology
Volume211
Issue number4
DOIs
Publication statusPublished - 1 Oct 2014

Keywords

  • cardiovascular risk
  • hypertensive pregnancy disorders
  • preeclampsia
  • pregnancy-induced hypertension

ASJC Scopus subject areas

  • Obstetrics and Gynaecology

Cite this

Visser, S., Hermes, W., Ket, J. C. F., Otten, R. H. J., van Pampus, M. G., Bloemenkamp, K. W. M., ... de Groot, C. J. M. (2014). Systematic review and metaanalysis on nonclassic cardiovascular biomarkers after hypertensive pregnancy disorders. American Journal of Obstetrics and Gynecology, 211(4), 373.e1-373.e9. https://doi.org/10.1016/j.ajog.2014.03.032
Visser, Sanne ; Hermes, Wietske ; Ket, Johannes C F ; Otten, René H J ; van Pampus, Maria G. ; Bloemenkamp, Kitty W M ; Franx, Arie ; Mol, Ben W. ; de Groot, Christianne J M. / Systematic review and metaanalysis on nonclassic cardiovascular biomarkers after hypertensive pregnancy disorders. In: American Journal of Obstetrics and Gynecology. 2014 ; Vol. 211, No. 4. pp. 373.e1-373.e9.
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abstract = "Objective The aim of this study was to investigate which nonclassic cardiovascular biomarkers are associated with persistent endothelial dysfunction after pregnancy in women with a history of hypertensive pregnancy disorders compared with women with uncomplicated pregnancies. Study Design This was a systematic review and metaanalysis of observational studies. A search was performed in PubMed, Embase, Cochrane, and Cinahl including articles from inception to Feb. 27, 2013. Included were cohort studies and case-control studies. Cases were women with a history of hypertension in pregnancy, control subjects were women with a history of uncomplicated pregnancies. Of the 3136 found, 21 studies on 16 nonclassic cardiovascular biomarkers are described in this review; 12 studies on 5 biomarkers were included in the metaanalysis.Results Women with a history of hypertensive pregnancy disorders had a higher homocysteine level compared with women with a history of uncomplicated pregnancies (5 studies; pooled mean difference, 0.77 ng/mL; 95{\%} confidence interval, 0.27-1.26; P <.01). For the other nonclassic cardiovascular biomarkers including markers in areas of inflammation, thrombosis, and angiogenesis, we found no significant differences.Conclusion This review and metaanalysis showed that women with a history of hypertensive pregnancy disorders have higher homocysteine levels compared with women with a history of uncomplicated pregnancies. These data suggest persistent endothelial alteration after pregnancies complicated by hypertensive disorders.",
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Visser, S, Hermes, W, Ket, JCF, Otten, RHJ, van Pampus, MG, Bloemenkamp, KWM, Franx, A, Mol, BW & de Groot, CJM 2014, 'Systematic review and metaanalysis on nonclassic cardiovascular biomarkers after hypertensive pregnancy disorders', American Journal of Obstetrics and Gynecology, vol. 211, no. 4, pp. 373.e1-373.e9. https://doi.org/10.1016/j.ajog.2014.03.032

Systematic review and metaanalysis on nonclassic cardiovascular biomarkers after hypertensive pregnancy disorders. / Visser, Sanne; Hermes, Wietske; Ket, Johannes C F; Otten, René H J; van Pampus, Maria G.; Bloemenkamp, Kitty W M; Franx, Arie; Mol, Ben W.; de Groot, Christianne J M.

In: American Journal of Obstetrics and Gynecology, Vol. 211, No. 4, 01.10.2014, p. 373.e1-373.e9.

Research output: Contribution to journalArticle

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AU - Visser, Sanne

AU - Hermes, Wietske

AU - Ket, Johannes C F

AU - Otten, René H J

AU - van Pampus, Maria G.

AU - Bloemenkamp, Kitty W M

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AU - Mol, Ben W.

AU - de Groot, Christianne J M

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N2 - Objective The aim of this study was to investigate which nonclassic cardiovascular biomarkers are associated with persistent endothelial dysfunction after pregnancy in women with a history of hypertensive pregnancy disorders compared with women with uncomplicated pregnancies. Study Design This was a systematic review and metaanalysis of observational studies. A search was performed in PubMed, Embase, Cochrane, and Cinahl including articles from inception to Feb. 27, 2013. Included were cohort studies and case-control studies. Cases were women with a history of hypertension in pregnancy, control subjects were women with a history of uncomplicated pregnancies. Of the 3136 found, 21 studies on 16 nonclassic cardiovascular biomarkers are described in this review; 12 studies on 5 biomarkers were included in the metaanalysis.Results Women with a history of hypertensive pregnancy disorders had a higher homocysteine level compared with women with a history of uncomplicated pregnancies (5 studies; pooled mean difference, 0.77 ng/mL; 95% confidence interval, 0.27-1.26; P <.01). For the other nonclassic cardiovascular biomarkers including markers in areas of inflammation, thrombosis, and angiogenesis, we found no significant differences.Conclusion This review and metaanalysis showed that women with a history of hypertensive pregnancy disorders have higher homocysteine levels compared with women with a history of uncomplicated pregnancies. These data suggest persistent endothelial alteration after pregnancies complicated by hypertensive disorders.

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