Systematic review and meta-analysis of intrauterine adhesions after miscarriage: Prevalence, risk factors and long-term reproductive outcome

Angelo B. Hooker, Marike Lemmers, Andreas L. Thurkow, Martijn W. Heymans, Brent C. Opmeer, Hans A M Brölmann, Ben W. Mol, Judith A F Huirne

Research output: Contribution to journalArticle

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Abstract

background: Approximately 15-20% of all clinically confirmed pregnancies end in a miscarriage. Intrauterine adhesions (IUAs) are a possible complication after miscarriage, but their prevalence and the contribution of possible risk factors have not been elucidated yet. In addition, the long-term reproductive outcome in relation to IUAs has to be elucidated. methods:We systematically searched the literature for studies that prospectively assessed the prevalence and extent of IUAs in women who suffered a miscarriage. To be included, women diagnosed with a current miscarriage had to be systematically evaluated within 12 months by hysteroscopy after either spontaneous expulsion or medical or surgical treatment. Studies that included women with a history of recurrent miscarriage only or that evaluated the IUAs after elective abortion or beyond 12 months after the last miscarriagewere not included. Subsequently, long-term reproductive outcomes after expectant (conservative), medical or surgical management were assessed in women with and without post-miscarriage IUAs. results:We included 10 prospective studies reporting on 912 women with hysteroscopic evaluation within 12 months of miscarriage and 8 prospective studies, including 1770 women, reporting long-term reproductive outcome. IUAs were detected in 183 women, resulting in a pooled prevalence of 19.1% [95% confidence interval (CI): 12.8-27.5%]. The extent of IUAs was reported in 124 women (67.8%) and was mild, moderate and severe respectively in 58.1, 28.2 and 13.7% of cases. Relative to women with one miscarriage, women with two or three or more miscarriages showed an increased risk of IUAs by a pooled OR of 1.41 and 2.1, respectively. The number of dilatation and curettage (D&C) procedures seemed to be the main driver behind these associations. A total of 150 congenital and acquired intrauterine abnormalities were encountered in 675 women, resulting in a pooled prevalence of 22.4% (95% CI: 16.3-29.9%). Similar reproductive outcomes were reported subsequent to conservative, medical or surgical management for miscarriage, although the numbers of studies and of included women were limited. No studies reported long-term reproductive outcomes following post-miscarriage IUAs. conclusions: IUAs are frequently encountered, in one in fivewomenafter miscarriage. In morethan half of these, the severity and extent of the adhesionswas mild, with unknown clinical relevance. Recurrent miscarriages andD&Cprocedures were identified as risk factors for adhesion formation.Congenital and acquired intrauterine abnormalities such as polyps or fibroids were frequently identified. Therewere no studies reporting on the link between IUAs and long-term reproductive outcome after miscarriage, while similar pregnancy outcomes were reported subsequent to conservative, medical or surgical management. Although this review does not allow strong clinical conclusions on treatment management, it signals an important clinical problem. Treatment strategies are proposed to minimize the number of D&C in an attempt to reduce IUAs.

LanguageEnglish
Article numberdmt045
Pages262-278
Number of pages17
JournalHuman Reproduction Update
Volume20
Issue number2
DOIs
Publication statusPublished - 1 Mar 2014

Keywords

  • Adhesions
  • Infertility
  • Miscarriage
  • Reproductive outcome
  • Systematic review

ASJC Scopus subject areas

  • Reproductive Medicine
  • Obstetrics and Gynaecology

Cite this

Hooker, A. B., Lemmers, M., Thurkow, A. L., Heymans, M. W., Opmeer, B. C., Brölmann, H. A. M., ... Huirne, J. A. F. (2014). Systematic review and meta-analysis of intrauterine adhesions after miscarriage: Prevalence, risk factors and long-term reproductive outcome. Human Reproduction Update, 20(2), 262-278. [dmt045]. https://doi.org/10.1093/humupd/dmt045
Hooker, Angelo B. ; Lemmers, Marike ; Thurkow, Andreas L. ; Heymans, Martijn W. ; Opmeer, Brent C. ; Brölmann, Hans A M ; Mol, Ben W. ; Huirne, Judith A F. / Systematic review and meta-analysis of intrauterine adhesions after miscarriage : Prevalence, risk factors and long-term reproductive outcome. In: Human Reproduction Update. 2014 ; Vol. 20, No. 2. pp. 262-278.
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abstract = "background: Approximately 15-20{\%} of all clinically confirmed pregnancies end in a miscarriage. Intrauterine adhesions (IUAs) are a possible complication after miscarriage, but their prevalence and the contribution of possible risk factors have not been elucidated yet. In addition, the long-term reproductive outcome in relation to IUAs has to be elucidated. methods:We systematically searched the literature for studies that prospectively assessed the prevalence and extent of IUAs in women who suffered a miscarriage. To be included, women diagnosed with a current miscarriage had to be systematically evaluated within 12 months by hysteroscopy after either spontaneous expulsion or medical or surgical treatment. Studies that included women with a history of recurrent miscarriage only or that evaluated the IUAs after elective abortion or beyond 12 months after the last miscarriagewere not included. Subsequently, long-term reproductive outcomes after expectant (conservative), medical or surgical management were assessed in women with and without post-miscarriage IUAs. results:We included 10 prospective studies reporting on 912 women with hysteroscopic evaluation within 12 months of miscarriage and 8 prospective studies, including 1770 women, reporting long-term reproductive outcome. IUAs were detected in 183 women, resulting in a pooled prevalence of 19.1{\%} [95{\%} confidence interval (CI): 12.8-27.5{\%}]. The extent of IUAs was reported in 124 women (67.8{\%}) and was mild, moderate and severe respectively in 58.1, 28.2 and 13.7{\%} of cases. Relative to women with one miscarriage, women with two or three or more miscarriages showed an increased risk of IUAs by a pooled OR of 1.41 and 2.1, respectively. The number of dilatation and curettage (D&C) procedures seemed to be the main driver behind these associations. A total of 150 congenital and acquired intrauterine abnormalities were encountered in 675 women, resulting in a pooled prevalence of 22.4{\%} (95{\%} CI: 16.3-29.9{\%}). Similar reproductive outcomes were reported subsequent to conservative, medical or surgical management for miscarriage, although the numbers of studies and of included women were limited. No studies reported long-term reproductive outcomes following post-miscarriage IUAs. conclusions: IUAs are frequently encountered, in one in fivewomenafter miscarriage. In morethan half of these, the severity and extent of the adhesionswas mild, with unknown clinical relevance. Recurrent miscarriages andD&Cprocedures were identified as risk factors for adhesion formation.Congenital and acquired intrauterine abnormalities such as polyps or fibroids were frequently identified. Therewere no studies reporting on the link between IUAs and long-term reproductive outcome after miscarriage, while similar pregnancy outcomes were reported subsequent to conservative, medical or surgical management. Although this review does not allow strong clinical conclusions on treatment management, it signals an important clinical problem. Treatment strategies are proposed to minimize the number of D&C in an attempt to reduce IUAs.",
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author = "Hooker, {Angelo B.} and Marike Lemmers and Thurkow, {Andreas L.} and Heymans, {Martijn W.} and Opmeer, {Brent C.} and Br{\"o}lmann, {Hans A M} and Mol, {Ben W.} and Huirne, {Judith A F}",
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Hooker, AB, Lemmers, M, Thurkow, AL, Heymans, MW, Opmeer, BC, Brölmann, HAM, Mol, BW & Huirne, JAF 2014, 'Systematic review and meta-analysis of intrauterine adhesions after miscarriage: Prevalence, risk factors and long-term reproductive outcome', Human Reproduction Update, vol. 20, no. 2, dmt045, pp. 262-278. https://doi.org/10.1093/humupd/dmt045

Systematic review and meta-analysis of intrauterine adhesions after miscarriage : Prevalence, risk factors and long-term reproductive outcome. / Hooker, Angelo B.; Lemmers, Marike; Thurkow, Andreas L.; Heymans, Martijn W.; Opmeer, Brent C.; Brölmann, Hans A M; Mol, Ben W.; Huirne, Judith A F.

In: Human Reproduction Update, Vol. 20, No. 2, dmt045, 01.03.2014, p. 262-278.

Research output: Contribution to journalArticle

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T2 - Human Reproduction Update

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AU - Thurkow, Andreas L.

AU - Heymans, Martijn W.

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AU - Huirne, Judith A F

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N2 - background: Approximately 15-20% of all clinically confirmed pregnancies end in a miscarriage. Intrauterine adhesions (IUAs) are a possible complication after miscarriage, but their prevalence and the contribution of possible risk factors have not been elucidated yet. In addition, the long-term reproductive outcome in relation to IUAs has to be elucidated. methods:We systematically searched the literature for studies that prospectively assessed the prevalence and extent of IUAs in women who suffered a miscarriage. To be included, women diagnosed with a current miscarriage had to be systematically evaluated within 12 months by hysteroscopy after either spontaneous expulsion or medical or surgical treatment. Studies that included women with a history of recurrent miscarriage only or that evaluated the IUAs after elective abortion or beyond 12 months after the last miscarriagewere not included. Subsequently, long-term reproductive outcomes after expectant (conservative), medical or surgical management were assessed in women with and without post-miscarriage IUAs. results:We included 10 prospective studies reporting on 912 women with hysteroscopic evaluation within 12 months of miscarriage and 8 prospective studies, including 1770 women, reporting long-term reproductive outcome. IUAs were detected in 183 women, resulting in a pooled prevalence of 19.1% [95% confidence interval (CI): 12.8-27.5%]. The extent of IUAs was reported in 124 women (67.8%) and was mild, moderate and severe respectively in 58.1, 28.2 and 13.7% of cases. Relative to women with one miscarriage, women with two or three or more miscarriages showed an increased risk of IUAs by a pooled OR of 1.41 and 2.1, respectively. The number of dilatation and curettage (D&C) procedures seemed to be the main driver behind these associations. A total of 150 congenital and acquired intrauterine abnormalities were encountered in 675 women, resulting in a pooled prevalence of 22.4% (95% CI: 16.3-29.9%). Similar reproductive outcomes were reported subsequent to conservative, medical or surgical management for miscarriage, although the numbers of studies and of included women were limited. No studies reported long-term reproductive outcomes following post-miscarriage IUAs. conclusions: IUAs are frequently encountered, in one in fivewomenafter miscarriage. In morethan half of these, the severity and extent of the adhesionswas mild, with unknown clinical relevance. Recurrent miscarriages andD&Cprocedures were identified as risk factors for adhesion formation.Congenital and acquired intrauterine abnormalities such as polyps or fibroids were frequently identified. Therewere no studies reporting on the link between IUAs and long-term reproductive outcome after miscarriage, while similar pregnancy outcomes were reported subsequent to conservative, medical or surgical management. Although this review does not allow strong clinical conclusions on treatment management, it signals an important clinical problem. Treatment strategies are proposed to minimize the number of D&C in an attempt to reduce IUAs.

AB - background: Approximately 15-20% of all clinically confirmed pregnancies end in a miscarriage. Intrauterine adhesions (IUAs) are a possible complication after miscarriage, but their prevalence and the contribution of possible risk factors have not been elucidated yet. In addition, the long-term reproductive outcome in relation to IUAs has to be elucidated. methods:We systematically searched the literature for studies that prospectively assessed the prevalence and extent of IUAs in women who suffered a miscarriage. To be included, women diagnosed with a current miscarriage had to be systematically evaluated within 12 months by hysteroscopy after either spontaneous expulsion or medical or surgical treatment. Studies that included women with a history of recurrent miscarriage only or that evaluated the IUAs after elective abortion or beyond 12 months after the last miscarriagewere not included. Subsequently, long-term reproductive outcomes after expectant (conservative), medical or surgical management were assessed in women with and without post-miscarriage IUAs. results:We included 10 prospective studies reporting on 912 women with hysteroscopic evaluation within 12 months of miscarriage and 8 prospective studies, including 1770 women, reporting long-term reproductive outcome. IUAs were detected in 183 women, resulting in a pooled prevalence of 19.1% [95% confidence interval (CI): 12.8-27.5%]. The extent of IUAs was reported in 124 women (67.8%) and was mild, moderate and severe respectively in 58.1, 28.2 and 13.7% of cases. Relative to women with one miscarriage, women with two or three or more miscarriages showed an increased risk of IUAs by a pooled OR of 1.41 and 2.1, respectively. The number of dilatation and curettage (D&C) procedures seemed to be the main driver behind these associations. A total of 150 congenital and acquired intrauterine abnormalities were encountered in 675 women, resulting in a pooled prevalence of 22.4% (95% CI: 16.3-29.9%). Similar reproductive outcomes were reported subsequent to conservative, medical or surgical management for miscarriage, although the numbers of studies and of included women were limited. No studies reported long-term reproductive outcomes following post-miscarriage IUAs. conclusions: IUAs are frequently encountered, in one in fivewomenafter miscarriage. In morethan half of these, the severity and extent of the adhesionswas mild, with unknown clinical relevance. Recurrent miscarriages andD&Cprocedures were identified as risk factors for adhesion formation.Congenital and acquired intrauterine abnormalities such as polyps or fibroids were frequently identified. Therewere no studies reporting on the link between IUAs and long-term reproductive outcome after miscarriage, while similar pregnancy outcomes were reported subsequent to conservative, medical or surgical management. Although this review does not allow strong clinical conclusions on treatment management, it signals an important clinical problem. Treatment strategies are proposed to minimize the number of D&C in an attempt to reduce IUAs.

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KW - Infertility

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