Synthetic analogues of bovine bactenecin dodecapeptide reduce herpes simplex virus type 2 infectivity in mice

Andrey Shestakov, Håvard Jenssen, Robert Hancock, Inger Nordström, Kristina Eriksson

Research output: Contribution to journalArticle

7 Citations (Scopus)

Abstract

We have evaluated the potential of four synthetic peptides (denoted HH-2, 1002, 1006, 1018) with a distant relationship to the host defense peptide bovine bactenecin dodecapeptide for their ability to prevent genital infections with herpes simplex virus type 2 (HSV-2) in mice. All four peptides showed antiviral properties in vitro and reduced HSV-2 infection of Vero cells in a dose-dependent manner. Detailed analysis showed that the peptides were able to interfere with both viral attachment and entry, but not with replication post-entry, and were effective antivirals also when HSV-2 was introduced in human semen. Two of the peptides proved especially effective in reducing HSV-2 infection also in vivo. When admixed with virus prior to inoculation, both HH-2 and 1018 reduced viral replication and disease development in a genital model of HSV-2 infection in mice, and also when using very high infectious doses of HSV-2. These data show that peptides HH-2 and 1018 have antiviral properties and can be used to prevent genital herpes infection in mice.

LanguageEnglish
Pages455-459
Number of pages5
JournalAntiviral Research
Volume100
Issue number2
DOIs
Publication statusPublished - 18 Oct 2013
Externally publishedYes

Keywords

  • Antimicrobial peptides
  • Bovine bactenecin
  • Genital herpes
  • HSV-2
  • Synthetic analogues

ASJC Scopus subject areas

  • Pharmacology
  • Virology

Cite this

Shestakov, Andrey ; Jenssen, Håvard ; Hancock, Robert ; Nordström, Inger ; Eriksson, Kristina. / Synthetic analogues of bovine bactenecin dodecapeptide reduce herpes simplex virus type 2 infectivity in mice. In: Antiviral Research. 2013 ; Vol. 100, No. 2. pp. 455-459.
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Synthetic analogues of bovine bactenecin dodecapeptide reduce herpes simplex virus type 2 infectivity in mice. / Shestakov, Andrey; Jenssen, Håvard; Hancock, Robert; Nordström, Inger; Eriksson, Kristina.

In: Antiviral Research, Vol. 100, No. 2, 18.10.2013, p. 455-459.

Research output: Contribution to journalArticle

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