Successful salvage of RAEB/AML relapsing early post allograft with FLAG-Ida conditioned mini-allograft: A report of two cases

C. H. Hui, P. Bardy, T. Hughes, N. Horvath, L. B. To

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Abstract

Management options are often limited for patients with AML or high grade myelodysplasia (MDS) relapsing within a year of allogeneic transplantation. We report, in two such patients, the use of re-induction with FLAG-Ida chemotherapy, followed by the infusion of GCSF-mobilized blood stem cells from the same HLA-matched donor. Both patients achieved durable complete remissions with good quality of life and longer disease-free survival than after the first myeloablative allografts. This mini-allograft approach offers a practical, well-tolerated salvage and a potentially curative treatment for relapsed AML/high grade MDS patients failing a first conventional myeloablative allogeneic transplants.

Original languageEnglish
Pages (from-to)135-138
Number of pages4
JournalClinical and Laboratory Haematology
Volume23
Issue number2
DOIs
Publication statusPublished or Issued - 23 Aug 2001

Keywords

  • FLAG-Ida
  • Mini-allograft
  • Relapsed AML
  • Second allograft

ASJC Scopus subject areas

  • Hematology

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