Structural and functional bases of visuospatial associative memory in older adults

Giovanna Zamboni, Celeste A. de Jager, Erin Drazich, Gwenaëlle Douaud, Mark Jenkinson, A. David Smith, Irene Tracey, Gordon K. Wilcock

Research output: Contribution to journalArticle

11 Citations (Scopus)

Abstract

Impaired visuospatial associative memory may be one of the earliest changes predicting cognitive impairment and Alzheimers disease. We explored the relationship between performance on a visuospatial associative memory task (the Placing Test) and brain structure and function in cognitively healthy older adults. First, we performed a voxel-based morphometry correlational analysis on structural magnetic resonance imaging (MRI) data from 144 healthy older adults with their scores on the Placing Test. Second, we carried out a functional MRI study on another group of 28 healthy older adults who performed a similar task during functional MRI. Decreased performance on the Placing Test was associated with increased atrophy in medial-temporal regions. Functional activation of the same regionscontrolling for the effect of atrophyoccurred during successful performance of the same task. The colocalization of structural and functional MRI correspondents of visuospatial associative test performance within medial-temporal regions validates multimodal imaging in describing behaviorally relevant variability in the aging brain and suggests that the Placing Test has the potential for detecting early cognitive changes occurring in preclinical phases of Alzheimer's disease.

LanguageEnglish
Pages961-972
Number of pages12
JournalNeurobiology of Aging
Volume34
Issue number3
DOIs
Publication statusPublished - 1 Mar 2013

Keywords

  • Hippocampus
  • Medial temporal lobe
  • Multimodal imaging
  • Placing test
  • VBM
  • Visuospatial associative memory
  • fMRI

ASJC Scopus subject areas

  • Neuroscience(all)
  • Ageing
  • Clinical Neurology
  • Developmental Biology
  • Geriatrics and Gerontology

Cite this

Zamboni, G., de Jager, C. A., Drazich, E., Douaud, G., Jenkinson, M., Smith, A. D., ... Wilcock, G. K. (2013). Structural and functional bases of visuospatial associative memory in older adults. Neurobiology of Aging, 34(3), 961-972. https://doi.org/10.1016/j.neurobiolaging.2012.07.011
Zamboni, Giovanna ; de Jager, Celeste A. ; Drazich, Erin ; Douaud, Gwenaëlle ; Jenkinson, Mark ; Smith, A. David ; Tracey, Irene ; Wilcock, Gordon K. / Structural and functional bases of visuospatial associative memory in older adults. In: Neurobiology of Aging. 2013 ; Vol. 34, No. 3. pp. 961-972.
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Zamboni, G, de Jager, CA, Drazich, E, Douaud, G, Jenkinson, M, Smith, AD, Tracey, I & Wilcock, GK 2013, 'Structural and functional bases of visuospatial associative memory in older adults', Neurobiology of Aging, vol. 34, no. 3, pp. 961-972. https://doi.org/10.1016/j.neurobiolaging.2012.07.011

Structural and functional bases of visuospatial associative memory in older adults. / Zamboni, Giovanna; de Jager, Celeste A.; Drazich, Erin; Douaud, Gwenaëlle; Jenkinson, Mark; Smith, A. David; Tracey, Irene; Wilcock, Gordon K.

In: Neurobiology of Aging, Vol. 34, No. 3, 01.03.2013, p. 961-972.

Research output: Contribution to journalArticle

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