Strategies for the treatment of imatinib-resistant chronic myeloid leukemia

Chi-hung Hui, Timothy P Hughes

Research output: Contribution to journalReview articlepeer-review


Treatment of chronic myeloid leukemia (CML) patients using imatinib alone is unlikely to be curative. The challenges in the era of imatinib are to prevent the emergence of imatinib resistance and to identify the most effective alternative approaches for patients who lose imatinib responsiveness. This review describes the possible strategies to overcome imatinib resistance in CML patients based on the current understanding of the action of imatinib and mechanisms of its resistance. The useful laboratory tests to study imatinib resistance and a current Australian CML study employing imatinib dose intensification and sequential combination therapy for newly diagnosed patients are also outlined.

Original languageEnglish
Pages (from-to)538-45, 559
JournalClinical advances in hematology & oncology : H&O
Issue number9
Publication statusPublished or Issued - Sep 2003
Externally publishedYes


  • Antineoplastic Agents
  • Antineoplastic Combined Chemotherapy Protocols
  • Benzamides
  • Drug Resistance, Neoplasm
  • Humans
  • Imatinib Mesylate
  • Leukemia, Myelogenous, Chronic, BCR-ABL Positive
  • Piperazines
  • Pyrimidines
  • Journal Article
  • Review

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