Strategies for the development of new PPAR agonists in diabetes

Matthew A. Cavender, Stephen Nicholls, A. Michael Lincoff

Research output: Contribution to journalReview article

5 Citations (Scopus)

Abstract

Diabetes is associated with a range of metabolic abnormalities including insulin resistance, atherogenic dyslipidemia, hypertension, and inflammation. These factors are likely to underlie the adverse cardiovascular outcome typically observed in diabetic cohorts. The family of peroxisome proliferator-activated receptors (PPARs) have been implicated in the regulation of a number of physiologic and metabolic pathways. Pharmacologic agonists directed against various PPARs have been shown to have a beneficial impact on these metabolic risk factors. The potential impact on cardiovascular risk with the use of PPAR agonists will be reviewed.

Original languageEnglish
JournalEuropean Journal of Cardiovascular Prevention and Rehabilitation
Volume17
Issue numberSUPPL. 1
DOIs
Publication statusPublished - 1 May 2010

Keywords

  • Coronary artery disease
  • Diabetes
  • Peroxisome proliferator- activated receptors
  • Prevention

ASJC Scopus subject areas

  • Epidemiology
  • Cardiology and Cardiovascular Medicine

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