Spotty Calcification as a marker of accelerated progression of coronary atherosclerosis: Insights from serial intravascular ultrasound

Yu Kataoka, Kathy Wolski, Kiyoko Uno, Rishi Puri, E. Murat Tuzcu, Steven E. Nissen, Stephen J. Nicholls

Research output: Contribution to journalArticle

90 Citations (Scopus)

Abstract

Objectives: The purpose of this study was to determine atheroma progression in patients with spotty calcification. Background: Although extensively calcified atherosclerotic lesions have been proposed to be clinically quiescent, the presence of spotty calcification within plaque has been reported to be associated with an increased incidence of ischemic cardiovascular events. The relationship between spotty calcification and disease progression has not been investigated. Methods: A total of 1,347 stable patients with angiographic coronary artery disease underwent serial evaluation of atheroma burden with intravascular ultrasound imaging. Patients with spotty calcification were identified based on the presence of lesions (1 to 4 mm in length) containing an arc of calcification of <90°. Clinical characteristics and disease progression were compared between patients with spotty calcification (n = 922) and those with no calcification (n = 425). Results: Patients with spotty calcification were older (age 56 years vs. 54 years; p = 0.001), more likely to be male (68% vs. 54%; p = 0.01), and have a history of diabetes mellitus (30% vs. 24%; p = 0.01) and myocardial infarction (28% vs. 20%; p = 0.004), and have lower on-treatment high-density lipoprotein cholesterol levels (48 ± 16 mg/dl vs. 51 ± 17 mg/dl; p = 0.001). Patients with spotty calcification demonstrated a greater percent atheroma volume (PAV) (36.0 ± 7.6% vs. 29.0 ± 8.5%; p < 0.001) and total atheroma volume (174.6 ± 71.9 mm 3 vs. 133.9 ± 64.9 mm 3; p < 0.001). On serial evaluation, spotty calcification was associated with greater progression of PAV (+0.43 ± 0.07% vs. +0.02 ± 0.11%; p = 0.002). Although intensive low-density lipoprotein cholesterol and blood pressure lowering therapy slowed disease progression, these efficacies were attenuated in patients with spotty calcification. Conclusions: The presence of spotty calcification is associated with more extensive and diffuse coronary atherosclerosis and accelerated disease progression despite use of medical therapies.

LanguageEnglish
Pages1592-1597
Number of pages6
JournalJournal of the American College of Cardiology
Volume59
Issue number18
DOIs
Publication statusPublished - 1 May 2012

Keywords

  • disease progression
  • intravascular ultrasound
  • spotty calcification

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

Cite this

Kataoka, Yu ; Wolski, Kathy ; Uno, Kiyoko ; Puri, Rishi ; Tuzcu, E. Murat ; Nissen, Steven E. ; Nicholls, Stephen J. / Spotty Calcification as a marker of accelerated progression of coronary atherosclerosis : Insights from serial intravascular ultrasound. In: Journal of the American College of Cardiology. 2012 ; Vol. 59, No. 18. pp. 1592-1597.
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abstract = "Objectives: The purpose of this study was to determine atheroma progression in patients with spotty calcification. Background: Although extensively calcified atherosclerotic lesions have been proposed to be clinically quiescent, the presence of spotty calcification within plaque has been reported to be associated with an increased incidence of ischemic cardiovascular events. The relationship between spotty calcification and disease progression has not been investigated. Methods: A total of 1,347 stable patients with angiographic coronary artery disease underwent serial evaluation of atheroma burden with intravascular ultrasound imaging. Patients with spotty calcification were identified based on the presence of lesions (1 to 4 mm in length) containing an arc of calcification of <90°. Clinical characteristics and disease progression were compared between patients with spotty calcification (n = 922) and those with no calcification (n = 425). Results: Patients with spotty calcification were older (age 56 years vs. 54 years; p = 0.001), more likely to be male (68{\%} vs. 54{\%}; p = 0.01), and have a history of diabetes mellitus (30{\%} vs. 24{\%}; p = 0.01) and myocardial infarction (28{\%} vs. 20{\%}; p = 0.004), and have lower on-treatment high-density lipoprotein cholesterol levels (48 ± 16 mg/dl vs. 51 ± 17 mg/dl; p = 0.001). Patients with spotty calcification demonstrated a greater percent atheroma volume (PAV) (36.0 ± 7.6{\%} vs. 29.0 ± 8.5{\%}; p < 0.001) and total atheroma volume (174.6 ± 71.9 mm 3 vs. 133.9 ± 64.9 mm 3; p < 0.001). On serial evaluation, spotty calcification was associated with greater progression of PAV (+0.43 ± 0.07{\%} vs. +0.02 ± 0.11{\%}; p = 0.002). Although intensive low-density lipoprotein cholesterol and blood pressure lowering therapy slowed disease progression, these efficacies were attenuated in patients with spotty calcification. Conclusions: The presence of spotty calcification is associated with more extensive and diffuse coronary atherosclerosis and accelerated disease progression despite use of medical therapies.",
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Spotty Calcification as a marker of accelerated progression of coronary atherosclerosis : Insights from serial intravascular ultrasound. / Kataoka, Yu; Wolski, Kathy; Uno, Kiyoko; Puri, Rishi; Tuzcu, E. Murat; Nissen, Steven E.; Nicholls, Stephen J.

In: Journal of the American College of Cardiology, Vol. 59, No. 18, 01.05.2012, p. 1592-1597.

Research output: Contribution to journalArticle

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T1 - Spotty Calcification as a marker of accelerated progression of coronary atherosclerosis

T2 - Journal of the American College of Cardiology

AU - Kataoka, Yu

AU - Wolski, Kathy

AU - Uno, Kiyoko

AU - Puri, Rishi

AU - Tuzcu, E. Murat

AU - Nissen, Steven E.

AU - Nicholls, Stephen J.

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N2 - Objectives: The purpose of this study was to determine atheroma progression in patients with spotty calcification. Background: Although extensively calcified atherosclerotic lesions have been proposed to be clinically quiescent, the presence of spotty calcification within plaque has been reported to be associated with an increased incidence of ischemic cardiovascular events. The relationship between spotty calcification and disease progression has not been investigated. Methods: A total of 1,347 stable patients with angiographic coronary artery disease underwent serial evaluation of atheroma burden with intravascular ultrasound imaging. Patients with spotty calcification were identified based on the presence of lesions (1 to 4 mm in length) containing an arc of calcification of <90°. Clinical characteristics and disease progression were compared between patients with spotty calcification (n = 922) and those with no calcification (n = 425). Results: Patients with spotty calcification were older (age 56 years vs. 54 years; p = 0.001), more likely to be male (68% vs. 54%; p = 0.01), and have a history of diabetes mellitus (30% vs. 24%; p = 0.01) and myocardial infarction (28% vs. 20%; p = 0.004), and have lower on-treatment high-density lipoprotein cholesterol levels (48 ± 16 mg/dl vs. 51 ± 17 mg/dl; p = 0.001). Patients with spotty calcification demonstrated a greater percent atheroma volume (PAV) (36.0 ± 7.6% vs. 29.0 ± 8.5%; p < 0.001) and total atheroma volume (174.6 ± 71.9 mm 3 vs. 133.9 ± 64.9 mm 3; p < 0.001). On serial evaluation, spotty calcification was associated with greater progression of PAV (+0.43 ± 0.07% vs. +0.02 ± 0.11%; p = 0.002). Although intensive low-density lipoprotein cholesterol and blood pressure lowering therapy slowed disease progression, these efficacies were attenuated in patients with spotty calcification. Conclusions: The presence of spotty calcification is associated with more extensive and diffuse coronary atherosclerosis and accelerated disease progression despite use of medical therapies.

AB - Objectives: The purpose of this study was to determine atheroma progression in patients with spotty calcification. Background: Although extensively calcified atherosclerotic lesions have been proposed to be clinically quiescent, the presence of spotty calcification within plaque has been reported to be associated with an increased incidence of ischemic cardiovascular events. The relationship between spotty calcification and disease progression has not been investigated. Methods: A total of 1,347 stable patients with angiographic coronary artery disease underwent serial evaluation of atheroma burden with intravascular ultrasound imaging. Patients with spotty calcification were identified based on the presence of lesions (1 to 4 mm in length) containing an arc of calcification of <90°. Clinical characteristics and disease progression were compared between patients with spotty calcification (n = 922) and those with no calcification (n = 425). Results: Patients with spotty calcification were older (age 56 years vs. 54 years; p = 0.001), more likely to be male (68% vs. 54%; p = 0.01), and have a history of diabetes mellitus (30% vs. 24%; p = 0.01) and myocardial infarction (28% vs. 20%; p = 0.004), and have lower on-treatment high-density lipoprotein cholesterol levels (48 ± 16 mg/dl vs. 51 ± 17 mg/dl; p = 0.001). Patients with spotty calcification demonstrated a greater percent atheroma volume (PAV) (36.0 ± 7.6% vs. 29.0 ± 8.5%; p < 0.001) and total atheroma volume (174.6 ± 71.9 mm 3 vs. 133.9 ± 64.9 mm 3; p < 0.001). On serial evaluation, spotty calcification was associated with greater progression of PAV (+0.43 ± 0.07% vs. +0.02 ± 0.11%; p = 0.002). Although intensive low-density lipoprotein cholesterol and blood pressure lowering therapy slowed disease progression, these efficacies were attenuated in patients with spotty calcification. Conclusions: The presence of spotty calcification is associated with more extensive and diffuse coronary atherosclerosis and accelerated disease progression despite use of medical therapies.

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