Spotty calcification and plaque vulnerability in vivo frequency-domain optical coherence tomography analysis

Yu Kataoka; Rishi Puri; Muhammad Hammadah; Bhanu Duggal; Kiyoko Uno; Samir R. Kapadia; E. Murat Tuzcu; Steven E. Nissen; Stephen J. Nicholls; Murat Tuzcu

doi:10.3978/j.issn.2223-3652.2014.11.06

Spotty calcification and plaque vulnerability in vivo frequency-domain optical coherence tomography analysis

Yu Kataoka, Rishi Puri, Muhammad Hammadah, Bhanu Duggal, Kiyoko Uno, Samir R. Kapadia, E. Murat Tuzcu, Steven E. Nissen, Stephen J. Nicholls, Murat Tuzcu

Heart And Vascular Health

Research output: Contribution to journal › Article

Abstract

Background: Spotty calcification is a morphological characteristic of a vulnerable plaque phenotype. While this calcium pattern is considered an active process, promoted by inflammation, it is unknown whether spotty calcification associates with development of microstructures observed in vulnerable plaques. As frequencydomain optical coherence tomography (FD-OCT) enables visualization of microstructures associated with plaque vulnerability, we investigated the association between spotty calcification and plaque microstructures by using FD-OCT. \r\n Methods: A total of 300 patients with stable coronary artery disease (CAD), having clinical indication for percutaneous coronary intervention (PCI), were analyzed. Totally 280 non-culprit lipid plaques within the target vessel requiring PCI were evaluated by FD-OCT. Spotty calcification was defined as a presence of lesion

Original language	English
Pages (from-to)	460-469
Number of pages	10
Journal	Cardiovascular Diagnosis and Therapy
Volume	4
Issue number	6
DOIs	https://doi.org/10.3978/j.issn.2223-3652.2014.11.06
Publication status	Published - 2014

Access to Document

10.3978/j.issn.2223-3652.2014.11.06

http://www.mendeley.com/research/spotty-calcification-plaque-vulnerability-vivo-frequencydomain-optical-coherence-tomography-analysis

Cite this

@article{b84760eeac004e948bd6b3ab49dafb47,

title = "Spotty calcification and plaque vulnerability in vivo frequency-domain optical coherence tomography analysis",

abstract = "Background: Spotty calcification is a morphological characteristic of a vulnerable plaque phenotype. While this calcium pattern is considered an active process, promoted by inflammation, it is unknown whether spotty calcification associates with development of microstructures observed in vulnerable plaques. As frequencydomain optical coherence tomography (FD-OCT) enables visualization of microstructures associated with plaque vulnerability, we investigated the association between spotty calcification and plaque microstructures by using FD-OCT. \r\n Methods: A total of 300 patients with stable coronary artery disease (CAD), having clinical indication for percutaneous coronary intervention (PCI), were analyzed. Totally 280 non-culprit lipid plaques within the target vessel requiring PCI were evaluated by FD-OCT. Spotty calcification was defined as a presence of lesion",

author = "Yu Kataoka and Rishi Puri and Muhammad Hammadah and Bhanu Duggal and Kiyoko Uno and Kapadia, {Samir R.} and Tuzcu, {E. Murat} and Nissen, {Steven E.} and Nicholls, {Stephen J.} and Murat Tuzcu",

year = "2014",

doi = "10.3978/j.issn.2223-3652.2014.11.06",

language = "English",

volume = "4",

pages = "460--469",

journal = "Cardiovascular Diagnosis and Therapy",

issn = "2223-3652",

publisher = "AME Publishing Company",

number = "6",

}

Spotty calcification and plaque vulnerability in vivo frequency-domain optical coherence tomography analysis. / Kataoka, Yu; Puri, Rishi; Hammadah, Muhammad; Duggal, Bhanu; Uno, Kiyoko; Kapadia, Samir R.; Tuzcu, E. Murat; Nissen, Steven E.; Nicholls, Stephen J.; Tuzcu, Murat.

In: Cardiovascular Diagnosis and Therapy, Vol. 4, No. 6, 2014, p. 460-469.

Research output: Contribution to journal › Article

TY - JOUR

T1 - Spotty calcification and plaque vulnerability in vivo frequency-domain optical coherence tomography analysis

AU - Kataoka, Yu

AU - Puri, Rishi

AU - Hammadah, Muhammad

AU - Duggal, Bhanu

AU - Uno, Kiyoko

AU - Kapadia, Samir R.

AU - Tuzcu, E. Murat

AU - Nissen, Steven E.

AU - Nicholls, Stephen J.

AU - Tuzcu, Murat

PY - 2014

Y1 - 2014

N2 - Background: Spotty calcification is a morphological characteristic of a vulnerable plaque phenotype. While this calcium pattern is considered an active process, promoted by inflammation, it is unknown whether spotty calcification associates with development of microstructures observed in vulnerable plaques. As frequencydomain optical coherence tomography (FD-OCT) enables visualization of microstructures associated with plaque vulnerability, we investigated the association between spotty calcification and plaque microstructures by using FD-OCT. \r\n Methods: A total of 300 patients with stable coronary artery disease (CAD), having clinical indication for percutaneous coronary intervention (PCI), were analyzed. Totally 280 non-culprit lipid plaques within the target vessel requiring PCI were evaluated by FD-OCT. Spotty calcification was defined as a presence of lesion

AB - Background: Spotty calcification is a morphological characteristic of a vulnerable plaque phenotype. While this calcium pattern is considered an active process, promoted by inflammation, it is unknown whether spotty calcification associates with development of microstructures observed in vulnerable plaques. As frequencydomain optical coherence tomography (FD-OCT) enables visualization of microstructures associated with plaque vulnerability, we investigated the association between spotty calcification and plaque microstructures by using FD-OCT. \r\n Methods: A total of 300 patients with stable coronary artery disease (CAD), having clinical indication for percutaneous coronary intervention (PCI), were analyzed. Totally 280 non-culprit lipid plaques within the target vessel requiring PCI were evaluated by FD-OCT. Spotty calcification was defined as a presence of lesion

U2 - 10.3978/j.issn.2223-3652.2014.11.06

DO - 10.3978/j.issn.2223-3652.2014.11.06

M3 - Article

C2 - 25610803

VL - 4

SP - 460

EP - 469

JO - Cardiovascular Diagnosis and Therapy

JF - Cardiovascular Diagnosis and Therapy

SN - 2223-3652

IS - 6

ER -