Splice factor mutations and alternative splicing as drivers of hematopoietic malignancy

Christopher N. Hahn, Parvathy Venugopal, Hamish s  Scott, Devendra Hiwase

Research output: Contribution to journalArticle

23 Citations (Scopus)

Abstract

Summary: Differential splicing contributes to the vast complexity of mRNA transcripts and protein isoforms that are necessary for cellular homeostasis and response to developmental cues and external signals. The hematopoietic system provides an exquisite example of this. Recently, discovery of mutations in components of the spliceosome in various hematopoietic malignancies (HMs) has led to an explosion in knowledge of the role of splicing and splice factors in HMs and other cancers. A better understanding of the mechanisms by which alternative splicing and aberrant splicing contributes to the leukemogenic process will enable more efficacious targeted approaches to tackle these often difficult to treat diseases. The clinical implications are only just starting to be realized with novel drug targets and therapeutic strategies open to exploitation for patient benefit.

Original languageEnglish
Pages (from-to)257-278
Number of pages22
JournalImmunological Reviews
Volume263
Issue number1
DOIs
Publication statusPublished - 1 Jan 2015
Externally publishedYes

Keywords

  • Alternative splicing
  • Hematopoiesis
  • Hematopoietic malignancy
  • Leukemogenesis
  • Splice factors

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology

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