Sperm penetration assay in predicting successful in vitro fertilization: A meta-analysis

Ben W J Mol, Saskia Meijer, Simone Yuppa, Erwin Tan, Jan De Vries, Patrick M M Bossuyt, Fulco Van Der Veen

Research output: Contribution to journalArticle

7 Citations (Scopus)

Abstract

OBJECTIVE: To determine if the performance of the sperm penetration assay (SPA) is useful in predicting successful in vitro fertilization (IVF). METHODS: A meta-analysis was set up to determine the performance of SPA in the prediction of IVF success. We collected data on 647 patients in 24 studies. For each study, a two-by-two table was constructed from the results of SPA and IVF. RESULTS: The sensitivity and specificity of SPA as compared to IVF were heterogeneous. A summary receiver operating characteristics curve could be estimated, showing that the sensitivity of SPA was only 37%, with a specificity of 95%. Subgroup analysis did not explain the lack of homogeneity. CONCLUSION: Since withholding IVF inappropriately has major consequences, performing SPA is insufficient for selecting patients for treatment with IVF embryo transfer.

LanguageEnglish
Pages503-508
Number of pages6
JournalJournal of Reproductive Medicine for the Obstetrician and Gynecologist
Volume43
Issue number6
Publication statusPublished - 1 Jun 1998

Keywords

  • Fertilization, in vitro
  • Infertility, female
  • Meta-analysis
  • Sperm penetration

ASJC Scopus subject areas

  • Reproductive Medicine
  • Obstetrics and Gynaecology

Cite this

Mol, B. W. J., Meijer, S., Yuppa, S., Tan, E., De Vries, J., Bossuyt, P. M. M., & Van Der Veen, F. (1998). Sperm penetration assay in predicting successful in vitro fertilization: A meta-analysis. Journal of Reproductive Medicine for the Obstetrician and Gynecologist, 43(6), 503-508.
Mol, Ben W J ; Meijer, Saskia ; Yuppa, Simone ; Tan, Erwin ; De Vries, Jan ; Bossuyt, Patrick M M ; Van Der Veen, Fulco. / Sperm penetration assay in predicting successful in vitro fertilization : A meta-analysis. In: Journal of Reproductive Medicine for the Obstetrician and Gynecologist. 1998 ; Vol. 43, No. 6. pp. 503-508.
@article{8f1a89a8818c4774b6618858060e5497,
title = "Sperm penetration assay in predicting successful in vitro fertilization: A meta-analysis",
abstract = "OBJECTIVE: To determine if the performance of the sperm penetration assay (SPA) is useful in predicting successful in vitro fertilization (IVF). METHODS: A meta-analysis was set up to determine the performance of SPA in the prediction of IVF success. We collected data on 647 patients in 24 studies. For each study, a two-by-two table was constructed from the results of SPA and IVF. RESULTS: The sensitivity and specificity of SPA as compared to IVF were heterogeneous. A summary receiver operating characteristics curve could be estimated, showing that the sensitivity of SPA was only 37{\%}, with a specificity of 95{\%}. Subgroup analysis did not explain the lack of homogeneity. CONCLUSION: Since withholding IVF inappropriately has major consequences, performing SPA is insufficient for selecting patients for treatment with IVF embryo transfer.",
keywords = "Fertilization, in vitro, Infertility, female, Meta-analysis, Sperm penetration",
author = "Mol, {Ben W J} and Saskia Meijer and Simone Yuppa and Erwin Tan and {De Vries}, Jan and Bossuyt, {Patrick M M} and {Van Der Veen}, Fulco",
year = "1998",
month = "6",
day = "1",
language = "English",
volume = "43",
pages = "503--508",
journal = "Journal of Reproductive Medicine for the Obstetrician and Gynecologist",
issn = "0024-7758",
publisher = "Donna Kessel",
number = "6",

}

Mol, BWJ, Meijer, S, Yuppa, S, Tan, E, De Vries, J, Bossuyt, PMM & Van Der Veen, F 1998, 'Sperm penetration assay in predicting successful in vitro fertilization: A meta-analysis', Journal of Reproductive Medicine for the Obstetrician and Gynecologist, vol. 43, no. 6, pp. 503-508.

Sperm penetration assay in predicting successful in vitro fertilization : A meta-analysis. / Mol, Ben W J; Meijer, Saskia; Yuppa, Simone; Tan, Erwin; De Vries, Jan; Bossuyt, Patrick M M; Van Der Veen, Fulco.

In: Journal of Reproductive Medicine for the Obstetrician and Gynecologist, Vol. 43, No. 6, 01.06.1998, p. 503-508.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Sperm penetration assay in predicting successful in vitro fertilization

T2 - Journal of Reproductive Medicine for the Obstetrician and Gynecologist

AU - Mol, Ben W J

AU - Meijer, Saskia

AU - Yuppa, Simone

AU - Tan, Erwin

AU - De Vries, Jan

AU - Bossuyt, Patrick M M

AU - Van Der Veen, Fulco

PY - 1998/6/1

Y1 - 1998/6/1

N2 - OBJECTIVE: To determine if the performance of the sperm penetration assay (SPA) is useful in predicting successful in vitro fertilization (IVF). METHODS: A meta-analysis was set up to determine the performance of SPA in the prediction of IVF success. We collected data on 647 patients in 24 studies. For each study, a two-by-two table was constructed from the results of SPA and IVF. RESULTS: The sensitivity and specificity of SPA as compared to IVF were heterogeneous. A summary receiver operating characteristics curve could be estimated, showing that the sensitivity of SPA was only 37%, with a specificity of 95%. Subgroup analysis did not explain the lack of homogeneity. CONCLUSION: Since withholding IVF inappropriately has major consequences, performing SPA is insufficient for selecting patients for treatment with IVF embryo transfer.

AB - OBJECTIVE: To determine if the performance of the sperm penetration assay (SPA) is useful in predicting successful in vitro fertilization (IVF). METHODS: A meta-analysis was set up to determine the performance of SPA in the prediction of IVF success. We collected data on 647 patients in 24 studies. For each study, a two-by-two table was constructed from the results of SPA and IVF. RESULTS: The sensitivity and specificity of SPA as compared to IVF were heterogeneous. A summary receiver operating characteristics curve could be estimated, showing that the sensitivity of SPA was only 37%, with a specificity of 95%. Subgroup analysis did not explain the lack of homogeneity. CONCLUSION: Since withholding IVF inappropriately has major consequences, performing SPA is insufficient for selecting patients for treatment with IVF embryo transfer.

KW - Fertilization, in vitro

KW - Infertility, female

KW - Meta-analysis

KW - Sperm penetration

UR - http://www.scopus.com/inward/record.url?scp=0031842409&partnerID=8YFLogxK

M3 - Article

VL - 43

SP - 503

EP - 508

JO - Journal of Reproductive Medicine for the Obstetrician and Gynecologist

JF - Journal of Reproductive Medicine for the Obstetrician and Gynecologist

SN - 0024-7758

IS - 6

ER -