Single-nucleotide polymorphism alleles in the insulin receptor gene are associated with typical migraine

Linda C. McCarthy, David A. Hosford, John H. Riley, Michael I. Bird, Nicola J. White, Duncan R. Hewett, Stephen J. Peroutka, Lyn R. Griffiths, Pete R. Boyd, Rod A. Lea, Shahid M. Bhatti, Louise K. Hosking, Chris M. Hood, Keith W. Jones, Abigail R. Handley, Raj Rallan, Karen F. Lewis, Astrid J.M. Yeo, Pauline M. Williams, Richard C. PriestParveen Khan, Christine Donnelly, Sheena M. Lumsden, Jennifer O'Sullivan, Chee Gee See, Devi H. Smart, Sue Shaw-Hawkins, Jaymini Patel, Tony C. Langrish, Wasyl Feniuk, Richard G. Knowles, Malcolm Thomas, Vincenzo Libri, Doug S. Montgomery, Penny K. Manasco, Chun Fang Xu, Colin Dykes, Patrick P.A. Humphrey, Allen D. Roses, Ian J. Purvis

Research output: Contribution to journalArticlepeer-review

108 Citations (Scopus)

Abstract

We have identified a migraine locus on chromosome 19p13.3/2 using linkage and association analysis. We isolated 48 single-nucleotide polymorphisms within the locus, of which we genotyped 24 in a Caucasian population comprising 827 unrelated cases and 765 controls. Five single-nucleotide polymorphisms within the insulin receptor gene showed significant association with migraine. This association was independently replicated in a case-control population collected separately. We used experiments with insulin receptor RNA and protein to investigate functionality for the migraine-associated single-nucleotide polymorphisms. We suggest possible functions for the insulin receptor in migraine pathogenesis.

Original languageEnglish
Pages (from-to)135-149
Number of pages15
JournalGenomics
Volume78
Issue number3
DOIs
Publication statusPublished or Issued - 15 Sep 2001
Externally publishedYes

Keywords

  • Association mapping
  • Complex disease
  • Disease susceptibility
  • Insulin receptor
  • Linkage disequilibrium mapping
  • Migraine
  • Migraine gene
  • SNPs

ASJC Scopus subject areas

  • Genetics

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