Signalling by the βc family of cytokines

Timothy R. Hercus, Urmi Dhagat, Winnie L T Kan, Sophie E. Broughton, Tracy L. Nero, Michelle Perugini, Jarrod J. Sandow, Richard J. D'Andrea, Paul G. Ekert, Timothy Hughes, Michael W. Parker, Angel F. Lopez

Research output: Contribution to journalReview article

43 Citations (Scopus)

Abstract

The GM-CSF, IL-3 and IL-5 family of cytokines, also known as the βc family due to their receptors sharing the signalling subunit βc, regulates multiple biological processes such as native and adaptive immunity, inflammation, normal and malignant hemopoieis, and autoimmunity. Australian scientists played a major role in the discovery and biological characterisation of the βc cytokines and their recent work is revealing unique features of cytokine receptor assembly and signalling. Furthermore, specific antibodies have been generated to modulate their function. Characterisation of the structural and dynamic requirements for the activation of the βc receptor family and the molecular definition of downstream signalling pathways are providing new insights into cytokine receptor signalling as well as new therapeutic opportunities.

Original languageEnglish
Pages (from-to)189-201
Number of pages13
JournalCytokine and Growth Factor Reviews
Volume24
Issue number3
DOIs
Publication statusPublished - 1 Jun 2013

Keywords

  • Cytokines
  • Inflammation
  • Leukaemia
  • Signalling
  • β Common receptor

ASJC Scopus subject areas

  • Endocrinology, Diabetes and Metabolism
  • Immunology and Allergy
  • Immunology
  • Biochemistry, Genetics and Molecular Biology(all)

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