@article{d8e53369ce8d4e7494fda72891f487f9,
title = "Signalling by the βc family of cytokines",
abstract = "The GM-CSF, IL-3 and IL-5 family of cytokines, also known as the βc family due to their receptors sharing the signalling subunit βc, regulates multiple biological processes such as native and adaptive immunity, inflammation, normal and malignant hemopoieis, and autoimmunity. Australian scientists played a major role in the discovery and biological characterisation of the βc cytokines and their recent work is revealing unique features of cytokine receptor assembly and signalling. Furthermore, specific antibodies have been generated to modulate their function. Characterisation of the structural and dynamic requirements for the activation of the βc receptor family and the molecular definition of downstream signalling pathways are providing new insights into cytokine receptor signalling as well as new therapeutic opportunities.",
keywords = "Cytokines, Inflammation, Leukaemia, Signalling, β Common receptor",
author = "Hercus, {Timothy R.} and Urmi Dhagat and Kan, {Winnie L T} and Broughton, {Sophie E.} and Nero, {Tracy L.} and Michelle Perugini and Sandow, {Jarrod J.} and D'Andrea, {Richard J.} and Ekert, {Paul G.} and Timothy Hughes and Parker, {Michael W.} and Lopez, {Angel F.}",
note = "Funding Information: Prof D{\textquoteright}Andrea is head of a joint research program with staff based in the Acute Leukaemia Laboratory at the Centre for Cancer Biology at SA Pathology (Frome Road) and the Haematology and Oncology laboratories at the Basil Hetzel Institute for Translational Health Research at the Queen Elizabeth Hospital. He has previously held a QEII Research Fellowship, the HM Lloyd Senior Research Fellowship in Oncology and the Peter Nelson Leukaemia Research Fellowship. He is an Affiliate Professor at the University of Adelaide, a full Member of the Hanson Institute and a Research Leader in the University of Adelaide Centre for Stem Cell Research and Centre for Personalised Cancer Medicine. Prof D{\textquoteright}Andrea has published extensively on myeloid leukemia, the molecular genetics of blood diseases and the biology of blood stem cells. He has been awarded funding for his research from the NH&MRC, the Australian Research Council, the USA National Institutes of Health, The Cancer Council of SA, The USA Leukaemia and Lymphoma Society, the Leukaemia Foundation of Australia, and Inner Wheel Australia. Funding Information: This work was supported by a National Health and Medical Research Council of Australia (NHMRC) Program Grant ( 565217 ) to A.F.L. and M.W.P. and NHMRC Project Grants ( 395512 , 559001 ) to T.R.H., M.W.P. and A.F.L. This work was also supported by Cancer Australia and the Victorian Cancer Council . This work was partly carried out in the Australian Cancer Research Foundation Rational Drug Discovery Centre. Infrastructure support from the NHMRC Independent Research Institutes Infrastructure Support Scheme and the Victorian State Government Operational Infrastructure Support Program to St. Vincent's Institute are gratefully acknowledged. T.H. is an NHMRC Practitioner Fellow. M.W.P. is an NHMRC Fellow (448300). T.R.H., S.E.B., U.D., T.H., A.F.L. and M.W.P. collaborate with the biopharmaceutical company CSL Ltd on therapeutic applications on some of the work presented here. ",
year = "2013",
month = jun,
doi = "10.1016/j.cytogfr.2013.03.002",
language = "English",
volume = "24",
pages = "189--201",
journal = "Cytokine and Growth Factor Reviews",
issn = "1359-6101",
publisher = "Elsevier BV",
number = "3",
}