@article{73be9f72aefd4b63b1bca9d5c3d2d441,
title = "Short Cationic Peptide Derived from Archaea with Dual Antibacterial Properties and Anti-Infective Potential",
abstract = "Bacterial biofilms and associated infections represent one of the biggest challenges in the clinic, and as an alternative to counter bacterial infections, antimicrobial peptides have attracted great attention in the past decade. Here, ten short cationic antimicrobial peptides were generated through a sliding-window strategy on the basis of the 19-amino acid residue peptide, derived from a Pyrobaculum aerophilum ribosomal protein. PaDBS1R6F10 exhibited anti-infective potential as it decreased the bacterial burden in murine Pseudomonas aeruginosa cutaneous infections by more than 1000-fold. Adverse cytotoxic and hemolytic effects were not detected against mammalian cells. The peptide demonstrated structural plasticity in terms of its secondary structure in the different environments tested. PaDBS1R6F10 represents a promising antimicrobial agent against bacteria infections, without harming human cells.",
keywords = "CD spectroscopy, antimicrobial peptide, biofilm, cutaneous infection",
author = "C{\^a}ndido, {Elizabete S.} and Cardoso, {Marlon H.} and Chan, {Lai Y.} and Torres, {Marcelo D.T.} and Oshiro, {Karen G.N.} and Porto, {William F.} and Ribeiro, {Suzana M.} and Haney, {Evan F.} and Hancock, {Robert E.W.} and Lu, {Timothy K.} and {De La Fuente-Nunez}, Cesar and Craik, {David J.} and Franco, {Oct{\'a}vio L.}",
note = "Funding Information: This work was supported by grants from Coordena{\c c}{\~a}o de Aperfei{\c c}oamento de Pessoal de N{\'i}vel Superior (CAPES) (to M.H.C. 88881.134423/2016-01), Conselho Nacional de Desenvolvimento e Tecnol{\'o}gico (CNPq) (to M.H.C. 141518/2015-4), Funda{\c c}{\~a}o de Apoio ao Desenvolvimento do Ensino, Ci{\^e}ncia e Tecnologia do Estado de Mato Grosso do Sul (FUNDECT), Brazil, Funda{\c c}{\~a}o de Apoio {\`a} Pesquisa do Distrito Federal (FAPDF), Ramon Areces Foundation (to C.F.-N.), DTRA (DTRA HDTRA1-15-1-0050) (to T.K.L.), and Funda{\c c}{\~a}o de Amparo {\`a} Pesquisa do Estado de S{\~a}o Paulo (M.D.T.T. # 2014/04507-5 and 2016/24413-0). D.J.C. is an ARC Australian Laureate Fellow (FL150100146). L.Y.C. was supported by the Advance Queensland Women{\textquoteright}s Academic Fund (WAF-6884942288). R.E.W.H. holds a Canada Research Chair. We thank Robin Kramer for her assistance with the skin scarification mouse model.",
year = "2019",
month = apr,
day = "24",
doi = "10.1021/acsinfecdis.9b00073",
language = "English",
volume = "5",
pages = "1081--1086",
journal = "ACS Infectious Diseases",
issn = "2373-8227",
publisher = "American Chemical Society",
number = "7",
}