TY - JOUR
T1 - Serum testosterone levels correlate with haemoglobin in middle-aged and older men
AU - Yeap, B. B.
AU - Beilin, J.
AU - Shi, Z.
AU - Knuiman, M. W.
AU - Olynyk, J. K.
AU - Bruce, D. G.
AU - Milward, E. A.
PY - 2009/8
Y1 - 2009/8
N2 - Background: Lower testosterone levels are associated with anaemia in older men and women. The relation between testosterone and haemoglobin (Hb) in younger and middle-aged men is less well defined. The aim of the study was to examine the association between testosterone and Hb levels in men spanning middle to older ages. Methods: A cross-sectional analysis of 492 men aged 30.7-94.5 years from the Busselton Health Survey, Western Australia, was carried out. Haemoglobin (Hb), early-morning serum total testosterone and sex hormone-binding globulin (SHBG) were measured. Free testosterone was calculated using mass action equations. Results: Haemoglobin correlated to total and free testosterone concentrations (r = 0.13, P = 0.003 and r = 0.20, P < 0.001, respectively). Hb and SHBG were inversely correlated (r = -0.14, P = 0.001). Hb increased across lowest to highest quartiles of total testosterone (P = 0.02) and free testosterone (P < 0.001), but not SHBG. After adjusting for age, waist circumference, smoking status, alcohol consumption, renal function and ferritin, total testosterone was associated with Hb (β = 0.037, P = 0.003) as was free testosterone (β = 2.32, P < 0.001), whereas SHBG was not associated. Conclusion: Testosterone concentration modulates Hb levels in community-dwelling men across a wide age range. Further studies are needed to clarify implications of this association between testosterone and Hb in men.
AB - Background: Lower testosterone levels are associated with anaemia in older men and women. The relation between testosterone and haemoglobin (Hb) in younger and middle-aged men is less well defined. The aim of the study was to examine the association between testosterone and Hb levels in men spanning middle to older ages. Methods: A cross-sectional analysis of 492 men aged 30.7-94.5 years from the Busselton Health Survey, Western Australia, was carried out. Haemoglobin (Hb), early-morning serum total testosterone and sex hormone-binding globulin (SHBG) were measured. Free testosterone was calculated using mass action equations. Results: Haemoglobin correlated to total and free testosterone concentrations (r = 0.13, P = 0.003 and r = 0.20, P < 0.001, respectively). Hb and SHBG were inversely correlated (r = -0.14, P = 0.001). Hb increased across lowest to highest quartiles of total testosterone (P = 0.02) and free testosterone (P < 0.001), but not SHBG. After adjusting for age, waist circumference, smoking status, alcohol consumption, renal function and ferritin, total testosterone was associated with Hb (β = 0.037, P = 0.003) as was free testosterone (β = 2.32, P < 0.001), whereas SHBG was not associated. Conclusion: Testosterone concentration modulates Hb levels in community-dwelling men across a wide age range. Further studies are needed to clarify implications of this association between testosterone and Hb in men.
KW - Free testosterone
KW - Haemoglobin
KW - Men
KW - Testosterone
UR - http://www.scopus.com/inward/record.url?scp=69549129504&partnerID=8YFLogxK
U2 - 10.1111/j.1445-5994.2008.01789.x
DO - 10.1111/j.1445-5994.2008.01789.x
M3 - Article
C2 - 19220545
AN - SCOPUS:69549129504
VL - 39
SP - 532
EP - 538
JO - Internal Medicine Journal
JF - Internal Medicine Journal
SN - 1444-0903
IS - 8
ER -