Serum S-adenosylmethionine, but not methionine, increases in response to overfeeding in humans

A. K. Elshorbagy, F. Jernerén, D. Samocha-Bonet, H. Refsum, Leonie Heilbronn

Research output: Contribution to journalArticle

13 Citations (Scopus)

Abstract

Background:Plasma concentration of the methyl donor S-adenosylmethionine (SAM) is linearly associated with body mass index (BMI) and fat mass. As SAM is a high-energy compound and a sensor of cellular nutrient status, we hypothesized that SAM would increase with overfeeding.Methods:Forty normal to overweight men and women were overfed by 1250 kcal per day for 28 days.Results:Serum SAM increased from 106 to 130 nmol/l (P=0.006). In stratified analysis, only those with weight gain above the median (high-weight gainers; average weight gain 3.9±0.3 kg) had increased SAM (+42%, P=0.001), whereas low-weight gainers (weight gain 1.5±0.2 kg) did not (P interaction =0.018). Overfeeding did not alter serum concentrations of the SAM precursor, methionine or the products, S-adenosyl-homocysteine and homocysteine. The SAM/SAH (S-adenosylhomocysteine) ratio was unchanged in the total population, but increased in high-weight gainers (+52%, P=0.006, P interaction =0.005). Change in SAM correlated positively with change in weight (r=0.33, P=0.041) and fat mass (r=0.44, P=0.009), but not with change in protein intake or plasma methionine, glucose, insulin or low-density lipoprotein (LDL)-cholesterol.Conclusion:Overfeeding raised serum SAM in proportion to the fat mass gained. The increase in SAM may help stabilize methionine levels, and denotes a responsiveness of SAM to nutrient state in humans. The role of SAM in human energy metabolism deserves further attention.

LanguageEnglish
Article numbere192
JournalNutrition and Diabetes
Volume6
DOIs
Publication statusPublished - 25 Jan 2016

ASJC Scopus subject areas

  • Internal Medicine
  • Endocrinology, Diabetes and Metabolism

Cite this

Elshorbagy, A. K., Jernerén, F., Samocha-Bonet, D., Refsum, H., & Heilbronn, L. (2016). Serum S-adenosylmethionine, but not methionine, increases in response to overfeeding in humans. Nutrition and Diabetes, 6, [e192]. https://doi.org/10.1038/nutd.2015.44
Elshorbagy, A. K. ; Jernerén, F. ; Samocha-Bonet, D. ; Refsum, H. ; Heilbronn, Leonie. / Serum S-adenosylmethionine, but not methionine, increases in response to overfeeding in humans. In: Nutrition and Diabetes. 2016 ; Vol. 6.
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abstract = "Background:Plasma concentration of the methyl donor S-adenosylmethionine (SAM) is linearly associated with body mass index (BMI) and fat mass. As SAM is a high-energy compound and a sensor of cellular nutrient status, we hypothesized that SAM would increase with overfeeding.Methods:Forty normal to overweight men and women were overfed by 1250 kcal per day for 28 days.Results:Serum SAM increased from 106 to 130 nmol/l (P=0.006). In stratified analysis, only those with weight gain above the median (high-weight gainers; average weight gain 3.9±0.3 kg) had increased SAM (+42{\%}, P=0.001), whereas low-weight gainers (weight gain 1.5±0.2 kg) did not (P interaction =0.018). Overfeeding did not alter serum concentrations of the SAM precursor, methionine or the products, S-adenosyl-homocysteine and homocysteine. The SAM/SAH (S-adenosylhomocysteine) ratio was unchanged in the total population, but increased in high-weight gainers (+52{\%}, P=0.006, P interaction =0.005). Change in SAM correlated positively with change in weight (r=0.33, P=0.041) and fat mass (r=0.44, P=0.009), but not with change in protein intake or plasma methionine, glucose, insulin or low-density lipoprotein (LDL)-cholesterol.Conclusion:Overfeeding raised serum SAM in proportion to the fat mass gained. The increase in SAM may help stabilize methionine levels, and denotes a responsiveness of SAM to nutrient state in humans. The role of SAM in human energy metabolism deserves further attention.",
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Serum S-adenosylmethionine, but not methionine, increases in response to overfeeding in humans. / Elshorbagy, A. K.; Jernerén, F.; Samocha-Bonet, D.; Refsum, H.; Heilbronn, Leonie.

In: Nutrition and Diabetes, Vol. 6, e192, 25.01.2016.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Serum S-adenosylmethionine, but not methionine, increases in response to overfeeding in humans

AU - Elshorbagy, A. K.

AU - Jernerén, F.

AU - Samocha-Bonet, D.

AU - Refsum, H.

AU - Heilbronn, Leonie

PY - 2016/1/25

Y1 - 2016/1/25

N2 - Background:Plasma concentration of the methyl donor S-adenosylmethionine (SAM) is linearly associated with body mass index (BMI) and fat mass. As SAM is a high-energy compound and a sensor of cellular nutrient status, we hypothesized that SAM would increase with overfeeding.Methods:Forty normal to overweight men and women were overfed by 1250 kcal per day for 28 days.Results:Serum SAM increased from 106 to 130 nmol/l (P=0.006). In stratified analysis, only those with weight gain above the median (high-weight gainers; average weight gain 3.9±0.3 kg) had increased SAM (+42%, P=0.001), whereas low-weight gainers (weight gain 1.5±0.2 kg) did not (P interaction =0.018). Overfeeding did not alter serum concentrations of the SAM precursor, methionine or the products, S-adenosyl-homocysteine and homocysteine. The SAM/SAH (S-adenosylhomocysteine) ratio was unchanged in the total population, but increased in high-weight gainers (+52%, P=0.006, P interaction =0.005). Change in SAM correlated positively with change in weight (r=0.33, P=0.041) and fat mass (r=0.44, P=0.009), but not with change in protein intake or plasma methionine, glucose, insulin or low-density lipoprotein (LDL)-cholesterol.Conclusion:Overfeeding raised serum SAM in proportion to the fat mass gained. The increase in SAM may help stabilize methionine levels, and denotes a responsiveness of SAM to nutrient state in humans. The role of SAM in human energy metabolism deserves further attention.

AB - Background:Plasma concentration of the methyl donor S-adenosylmethionine (SAM) is linearly associated with body mass index (BMI) and fat mass. As SAM is a high-energy compound and a sensor of cellular nutrient status, we hypothesized that SAM would increase with overfeeding.Methods:Forty normal to overweight men and women were overfed by 1250 kcal per day for 28 days.Results:Serum SAM increased from 106 to 130 nmol/l (P=0.006). In stratified analysis, only those with weight gain above the median (high-weight gainers; average weight gain 3.9±0.3 kg) had increased SAM (+42%, P=0.001), whereas low-weight gainers (weight gain 1.5±0.2 kg) did not (P interaction =0.018). Overfeeding did not alter serum concentrations of the SAM precursor, methionine or the products, S-adenosyl-homocysteine and homocysteine. The SAM/SAH (S-adenosylhomocysteine) ratio was unchanged in the total population, but increased in high-weight gainers (+52%, P=0.006, P interaction =0.005). Change in SAM correlated positively with change in weight (r=0.33, P=0.041) and fat mass (r=0.44, P=0.009), but not with change in protein intake or plasma methionine, glucose, insulin or low-density lipoprotein (LDL)-cholesterol.Conclusion:Overfeeding raised serum SAM in proportion to the fat mass gained. The increase in SAM may help stabilize methionine levels, and denotes a responsiveness of SAM to nutrient state in humans. The role of SAM in human energy metabolism deserves further attention.

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JF - Nutrition and Diabetes

SN - 2044-4052

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