Serum leptin concentration, obesity, and insulin resistance in Western Samoans: Cross sectional study

Paul Zimmet, Allison Hodge, Margery Nicolson, Myrlene Staten, Maximilian De Courten, Jason Moore, Andrew Morawiecki, John Lubina, Gregory Collier, George Alberti, Gary Dowse

Research output: Contribution to journalArticle

200 Citations (Scopus)

Abstract

Objective - To measure serum leptin concentrations in the Polynesian population of Western Samoa and to examine epidemiological associations of leptin with anthropometric, demographic, behavioural, and metabolic factors in this population with a high prevalence of obesity and non-insulin dependent diabetes mellitus. Design - Cross sectional study, leptin concentration being measured in a subgroup of a population based sample. Subjects - 240 Polynesian men and women aged 28-74 years were selected to cover the full range of age, body mass index, and glucose tolerance. Main outcome measurements - Serum leptin, insulin, and glucose concentrations; anthropometric measures; physical activity; and area of residence. Results - Leptin concentrations were correlated with body mass index (r = 0.80 in men, 0.79 in women) and waist circumference (r = 0.82 in men, 0.78 in women) but less so with waist to hip ratio. At any body mass index, leptin concentration was higher in women than men (geometric mean adjusted for body mass index 15.3 v 3.6 pg/l, P < 0.001). Leptin concentration also correlated with fasting insulin concentration (r = 0.63 in men, 0.64 in women) and insulin concentration 2 hours after a glucose load (r = 0.58 in men, 0.52 in women). These associations remained significant after controlling for body mass index; effects of physical activity and of rural or urban living on leptin concentration were eliminated after adjusting for obesity, except values remained high in urban men. 78% of variance in leptin was explained by a model including fasting insulin concentration, sex, body mass index, and a body mass index by sex interaction term. Similar results were obtained if waist circumference replaced body mass index. Conclusions - The strong relation of leptin with obesity is consistent with leptin production being proportional to mass of adipose tissue. The relation with insulin independent of body mass index suggests a possible role for leptin in insulin resistance or hyperinsulinaemia.

LanguageEnglish
Pages965-969
Number of pages5
JournalBritish Medical Journal
Volume313
Issue number7063
Publication statusPublished - 28 Nov 1996

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Zimmet, P., Hodge, A., Nicolson, M., Staten, M., De Courten, M., Moore, J., ... Dowse, G. (1996). Serum leptin concentration, obesity, and insulin resistance in Western Samoans: Cross sectional study. British Medical Journal, 313(7063), 965-969.
Zimmet, Paul ; Hodge, Allison ; Nicolson, Margery ; Staten, Myrlene ; De Courten, Maximilian ; Moore, Jason ; Morawiecki, Andrew ; Lubina, John ; Collier, Gregory ; Alberti, George ; Dowse, Gary. / Serum leptin concentration, obesity, and insulin resistance in Western Samoans : Cross sectional study. In: British Medical Journal. 1996 ; Vol. 313, No. 7063. pp. 965-969.
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Zimmet, P, Hodge, A, Nicolson, M, Staten, M, De Courten, M, Moore, J, Morawiecki, A, Lubina, J, Collier, G, Alberti, G & Dowse, G 1996, 'Serum leptin concentration, obesity, and insulin resistance in Western Samoans: Cross sectional study', British Medical Journal, vol. 313, no. 7063, pp. 965-969.

Serum leptin concentration, obesity, and insulin resistance in Western Samoans : Cross sectional study. / Zimmet, Paul; Hodge, Allison; Nicolson, Margery; Staten, Myrlene; De Courten, Maximilian; Moore, Jason; Morawiecki, Andrew; Lubina, John; Collier, Gregory; Alberti, George; Dowse, Gary.

In: British Medical Journal, Vol. 313, No. 7063, 28.11.1996, p. 965-969.

Research output: Contribution to journalArticle

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Zimmet P, Hodge A, Nicolson M, Staten M, De Courten M, Moore J et al. Serum leptin concentration, obesity, and insulin resistance in Western Samoans: Cross sectional study. British Medical Journal. 1996 Nov 28;313(7063):965-969.