Semiphysiologically based pharmacokinetic model of leflunomide disposition in rheumatoid arthritis patients

A. M. Hopkins, M. D. Wiese, S. M. Proudman, C. E. O'Doherty, D. J.R. Foster, R. N. Upton

Research output: Contribution to journalArticlepeer-review

13 Citations (Scopus)

Abstract

A semiphysiologically based pharmacokinetic (semi-PBPK) population model was used to evaluate the influence of enterohepatic recycling and protein binding, as well as the effect of genetic variability in CYP1A2, CYP2C19, and ABCG2, on the large interindividual variability of teriflunomide (active metabolite) concentrations following leflunomide administration in rheumatoid arthritis (RA) patients. The model was developed with total and free teriflunomide concentrations determined in RA patients taking leflunomide, as well as mean teriflunomide concentrations following the administration of leflunomide or teriflunomide extracted from the literature. Once developed, the 15-compartment model was able to predict total and free teriflunomide concentrations and was used to screen demographic and genotypic covariates, of which only fat-free mass and liver function (ALT) improved prediction. This approach effectively evaluated the effects of multiple covariates on both total and free teriflunomide concentrations, which have only been explored previously through simplistic one-compartment models for total teriflunomide.

Original languageEnglish
Pages (from-to)362-371
Number of pages10
JournalCPT: Pharmacometrics and Systems Pharmacology
Volume4
Issue number6
DOIs
Publication statusPublished or Issued - 1 Jun 2015
Externally publishedYes

ASJC Scopus subject areas

  • Modelling and Simulation
  • Pharmacology (medical)

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