Selenoprotein P is elevated in individuals with obesity, but is not independently associated with insulin resistance

Miaoxin Chen, Bo Liu, David Wilkinson, Amy T. Hutchison, Campbell H. Thompson, Gary A. Wittert, Leonie K. Heilbronn

Research output: Contribution to journalArticlepeer-review

19 Citations (Scopus)

Abstract

Selenoprotein P (SeP) is secreted primarily by the liver and postulated to cause insulin resistance. The aim of this study was to measure plasma SeP in individuals who are lean (N = 29) or overweight/obese (N = 34), and examine relationships between circulating SeP, SEPP1 (SeP, plasma 1) expression in subcutaneous adipose tissue, and markers of insulin resistance. SeP was higher in individuals who were overweight/obese (P < 0.001), and associated with insulin resistance by HOMA-IR and by clamp, but not independently of BMI. SEPP1 mRNA was correlated negatively with BMI, suggesting there may be tissue specific regulation. This study suggests that obesity, rather than insulin resistance, is central to the increase in SeP.

Original languageEnglish
Pages (from-to)227-232
Number of pages6
JournalObesity Research and Clinical Practice
Volume11
Issue number2
DOIs
Publication statusPublished or Issued - Mar 2017

Keywords

  • Insulin resistance
  • Obesity
  • Selenoprotein P

ASJC Scopus subject areas

  • Endocrinology, Diabetes and Metabolism
  • Nutrition and Dietetics

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