SCN1A variations and response to multiple antiepileptic drugs

T. S.C. Yip, C. O'Doherty, N. C.K. Tan, L. M. Dibbens, V. Suppiah

Research output: Contribution to journalArticlepeer-review

13 Citations (Scopus)

Abstract

In the current study, we have used the haplotype-tagging single-nucleotide polymorphisms (SNPs) to determine associations between genetic variants in SCN1A and treatment response in 519 Caucasian patients with known response status for epilepsy treated with antiepileptic drugs (AEDs) with sodium channel blocking effects. Nine SNPs within SCN1A were genotyped in this cohort. The only association observed was for rs10188577. A greater proportion of drug-resistant patients were heterozygous compared with drug responsive patients (48.3% vs 35.4%, P=0.014). After correction for potential confounding factors, the association for rs10188577 was only marginally significant (P=0.049). In light of our findings, it seems unlikely that rs10188577 could be a major determinant of response to AEDs. However, looking at the influence of rs10188577 on the expressed quantitative trait association patterns within the immediate vicinity of SCN1A, we found significant associations with neighbouring sodium channel genes, SCN7A and SCN9A (P<0.025), which warrants further studies.

Original languageEnglish
Pages (from-to)385-389
Number of pages5
JournalPharmacogenomics Journal
Volume14
Issue number4
DOIs
Publication statusPublished or Issued - Aug 2014

Keywords

  • SCN1A
  • epilepsy
  • pharmacogenetics

ASJC Scopus subject areas

  • Molecular Medicine
  • Genetics
  • Pharmacology

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