Runs of homozygosity and a cluster of vulvar cancer in young Australian Aboriginal women

Rebekah E. Mcwhirter, Russell J. Thomson, James R. Marthick, Alice Rumbold, Matthew A. Brown, Debbie Taylor-Thomson, Elaine L. Maypilama, John R. Condon, Joanne L. Dickinson

Research output: Contribution to journalArticle

8 Citations (Scopus)

Abstract

Objective A cluster of vulvar cancer exists in young Aboriginal women living in remote communities in Arnhem Land, Australia. A genetic case-control study was undertaken involving 30 cases of invasive vulvar cancer and its precursor lesion, high-grade vulvar intraepithelial neoplasia (VIN), and 61 controls, matched for age and community of residence. It was hypothesized that this small, isolated population may exhibit increased autozygosity, implicating recessive effects as a possible mechanism for increased susceptibility to vulvar cancer. Methods Genotyping data from saliva samples were used to identify runs of homozygosity (ROH) in order to calculate estimates of genome-wide homozygosity. Results No evidence of an effect of genome-wide homozygosity on vulvar cancer and VIN in East Arnhem women was found, nor was any individual ROH found to be significantly associated with case status. This study found further evidence supporting an association between previous diagnosis of CIN and diagnosis of vulvar cancer or VIN, but found no association with any other medical history variable. Conclusions These findings do not eliminate the possibility of genetic risk factors being involved in this cancer cluster, but rather suggest that alternative analytical strategies and genetic models should be explored.

LanguageEnglish
Pages421-426
Number of pages6
JournalGynecologic Oncology
Volume133
Issue number3
DOIs
Publication statusPublished - 1 Jan 2014
Externally publishedYes

Keywords

  • Aboriginal and Torres Strait Islander peoples
  • Genetic risk factors
  • Homozygosity
  • Human papillomavirus
  • Vulvar cancer
  • Vulvar intraepithelial neoplasia

ASJC Scopus subject areas

  • Oncology
  • Obstetrics and Gynaecology

Cite this

Mcwhirter, R. E., Thomson, R. J., Marthick, J. R., Rumbold, A., Brown, M. A., Taylor-Thomson, D., ... Dickinson, J. L. (2014). Runs of homozygosity and a cluster of vulvar cancer in young Australian Aboriginal women. Gynecologic Oncology, 133(3), 421-426. https://doi.org/10.1016/j.ygyno.2014.03.566
Mcwhirter, Rebekah E. ; Thomson, Russell J. ; Marthick, James R. ; Rumbold, Alice ; Brown, Matthew A. ; Taylor-Thomson, Debbie ; Maypilama, Elaine L. ; Condon, John R. ; Dickinson, Joanne L. / Runs of homozygosity and a cluster of vulvar cancer in young Australian Aboriginal women. In: Gynecologic Oncology. 2014 ; Vol. 133, No. 3. pp. 421-426.
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Mcwhirter, RE, Thomson, RJ, Marthick, JR, Rumbold, A, Brown, MA, Taylor-Thomson, D, Maypilama, EL, Condon, JR & Dickinson, JL 2014, 'Runs of homozygosity and a cluster of vulvar cancer in young Australian Aboriginal women', Gynecologic Oncology, vol. 133, no. 3, pp. 421-426. https://doi.org/10.1016/j.ygyno.2014.03.566

Runs of homozygosity and a cluster of vulvar cancer in young Australian Aboriginal women. / Mcwhirter, Rebekah E.; Thomson, Russell J.; Marthick, James R.; Rumbold, Alice; Brown, Matthew A.; Taylor-Thomson, Debbie; Maypilama, Elaine L.; Condon, John R.; Dickinson, Joanne L.

In: Gynecologic Oncology, Vol. 133, No. 3, 01.01.2014, p. 421-426.

Research output: Contribution to journalArticle

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T1 - Runs of homozygosity and a cluster of vulvar cancer in young Australian Aboriginal women

AU - Mcwhirter, Rebekah E.

AU - Thomson, Russell J.

AU - Marthick, James R.

AU - Rumbold, Alice

AU - Brown, Matthew A.

AU - Taylor-Thomson, Debbie

AU - Maypilama, Elaine L.

AU - Condon, John R.

AU - Dickinson, Joanne L.

PY - 2014/1/1

Y1 - 2014/1/1

N2 - Objective A cluster of vulvar cancer exists in young Aboriginal women living in remote communities in Arnhem Land, Australia. A genetic case-control study was undertaken involving 30 cases of invasive vulvar cancer and its precursor lesion, high-grade vulvar intraepithelial neoplasia (VIN), and 61 controls, matched for age and community of residence. It was hypothesized that this small, isolated population may exhibit increased autozygosity, implicating recessive effects as a possible mechanism for increased susceptibility to vulvar cancer. Methods Genotyping data from saliva samples were used to identify runs of homozygosity (ROH) in order to calculate estimates of genome-wide homozygosity. Results No evidence of an effect of genome-wide homozygosity on vulvar cancer and VIN in East Arnhem women was found, nor was any individual ROH found to be significantly associated with case status. This study found further evidence supporting an association between previous diagnosis of CIN and diagnosis of vulvar cancer or VIN, but found no association with any other medical history variable. Conclusions These findings do not eliminate the possibility of genetic risk factors being involved in this cancer cluster, but rather suggest that alternative analytical strategies and genetic models should be explored.

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