Role of spiral wave pinning in inhomogeneous active media in the termination of atrial fibrillation by electrical cardioversion

Pawel Kuklik, Christopher X. Wong, Anthony G. Brooks, Jan Jacek Zebrowski, Prashanthan Sanders

Research output: Contribution to journalArticlepeer-review

1 Citation (Scopus)

Abstract

Atrial fibrillation is the most common type of arrhythmia to affect humans. One of the treatment modalities for atrial fibrillation is an electrical cardioversion. Electrical cardioversion can result in one of three outcomes: an immediate termination of arrhythmic activity, a delayed termination or unsuccessful termination. The mechanism of delayed termination is unknown. Here we present a model of an atrial fibrillation as a coexistence of several spiral waves pinned to the inhomogeneities in active media. We show that in inhomogeneous system delayed termination can be explained as the unpinning of a spiral wave from inhomogeneities and its termination after collision with the edge of the system.

Original languageEnglish
Pages (from-to)363-372
Number of pages10
JournalComputers in Biology and Medicine
Volume40
Issue number3
DOIs
Publication statusPublished or Issued - Mar 2010

Keywords

  • Arrhythmia mechanisms
  • Atrial fibrillation
  • Electrical cardioversion
  • Excitable media
  • Spiral wave pinning

ASJC Scopus subject areas

  • Computer Science Applications
  • Health Informatics

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