Rodent whole-body sectioning and MALDI mass spectrometry imaging

Research output: Chapter in Book/Report/Conference proceedingChapter

5 Citations (Scopus)

Abstract

Here, we describe a method for obtaining whole-body MALDI imaging data. MALDI imaging provides chemical compound-specific information not attainable with conventional histology techniques. The specificity of mass spectrometry with the addition of spatial information makes this a very powerful technique, especially for the analysis of endogenous and exogenous small molecules. This chapter will provide the reader with a comprehensive description of the techniques involved in obtaining high-quality MALDI mass spectrometry imaging (MSI) data from large tissue sections.

Original languageEnglish
Title of host publicationMethods in Molecular Biology
PublisherHumana Press Inc.
Pages175-189
Number of pages15
Volume1618
DOIs
Publication statusPublished - 2017

Publication series

NameMethods in Molecular Biology
Volume1618
ISSN (Print)1064-3745

Keywords

  • MALDI imaging mass spectrometry
  • QWBA
  • Whole-body

ASJC Scopus subject areas

  • Molecular Biology
  • Genetics

Cite this

Trim, P. J. (2017). Rodent whole-body sectioning and MALDI mass spectrometry imaging. In Methods in Molecular Biology (Vol. 1618, pp. 175-189). (Methods in Molecular Biology; Vol. 1618). Humana Press Inc.. https://doi.org/10.1007/978-1-4939-7051-3_15