Risk factors for coronary heart disease in a population with a high prevalence of obesity and diabetes: A case-control study of the polynesian population of Western Samoa

Sudhir Wahi, Christoph D. Gatzka, Bridget Sherrard, Harrison Simpson, Veronica Collins, Gary Dowse, Paul Zimmet, Garry Jennings, Anthony M. Dart

Research output: Contribution to journalArticle

15 Citations (Scopus)

Abstract

Objective: To evaluate anthropometric, haemodynamic and biochemical risk markers for coronary heart disease (CHD) in the Polynesian population of Western Samoa in a case-control study of 43 cases of CHD compared with 90 age- (mean 53 years) and sex-matched controls. Methods: Cases were identified on the basis of a 12-lead electrocardiogram and clinical history. Results: More than 60% of the participants had a body mass index ≤30 kg/m2 and nearly 80% had central obesity. Both diabetes mellitus (17%) and impaired glucose tolerance (9%) were also common in this population. Nineteen per cent of the population were hypertensive and both antihypertensive therapy (21 versus 1%, P<0.001, risk 23.6) and hypertension (35 versus 11%, P<0.01, risk 4.3) were significantly more common among cases than they were among controls. In addition, the plasma high-density lipoprotein cholesterol level was lower (1.00±0.09 versus 1.94±0.05 mmol/l, P<0.05) and the plasma urate level was higher (0.42±0.02 versus 0.37±0.01 mmol/l, P<0.05) in the female cases than they were in their respective controls. Low-density lipoprotein (LDL) particle sizing did not reveal an excess of small LDL particles to be a feature of CHD cases, but more than 70% both of cases and of controls had multiple LDL species. The response of the triglyceride level to a fat-rich meal was the same for CHD cases and controls. Conclusion: The population studied had a high prevalence of several risk factors for CHD, including obesity and non-insulin-dependent diabetes mellitus; however, the most prominent factor relating to CHD within the community was the presence of hypertension.

LanguageEnglish
Pages173-178
Number of pages6
JournalJournal of Cardiovascular Risk
Volume4
Issue number3
DOIs
Publication statusPublished - 1997

Keywords

  • Coronary heart disease
  • Diabetes
  • Hypertension
  • Low-density lipoprotein particle size
  • Obesity
  • Polynesian
  • Risk factors
  • Samoa

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

Cite this

Wahi, Sudhir ; Gatzka, Christoph D. ; Sherrard, Bridget ; Simpson, Harrison ; Collins, Veronica ; Dowse, Gary ; Zimmet, Paul ; Jennings, Garry ; Dart, Anthony M. / Risk factors for coronary heart disease in a population with a high prevalence of obesity and diabetes : A case-control study of the polynesian population of Western Samoa. In: Journal of Cardiovascular Risk. 1997 ; Vol. 4, No. 3. pp. 173-178.
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Risk factors for coronary heart disease in a population with a high prevalence of obesity and diabetes : A case-control study of the polynesian population of Western Samoa. / Wahi, Sudhir; Gatzka, Christoph D.; Sherrard, Bridget; Simpson, Harrison; Collins, Veronica; Dowse, Gary; Zimmet, Paul; Jennings, Garry; Dart, Anthony M.

In: Journal of Cardiovascular Risk, Vol. 4, No. 3, 1997, p. 173-178.

Research output: Contribution to journalArticle

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T1 - Risk factors for coronary heart disease in a population with a high prevalence of obesity and diabetes

T2 - Journal of Cardiovascular Risk

AU - Wahi, Sudhir

AU - Gatzka, Christoph D.

AU - Sherrard, Bridget

AU - Simpson, Harrison

AU - Collins, Veronica

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AU - Jennings, Garry

AU - Dart, Anthony M.

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AB - Objective: To evaluate anthropometric, haemodynamic and biochemical risk markers for coronary heart disease (CHD) in the Polynesian population of Western Samoa in a case-control study of 43 cases of CHD compared with 90 age- (mean 53 years) and sex-matched controls. Methods: Cases were identified on the basis of a 12-lead electrocardiogram and clinical history. Results: More than 60% of the participants had a body mass index ≤30 kg/m2 and nearly 80% had central obesity. Both diabetes mellitus (17%) and impaired glucose tolerance (9%) were also common in this population. Nineteen per cent of the population were hypertensive and both antihypertensive therapy (21 versus 1%, P<0.001, risk 23.6) and hypertension (35 versus 11%, P<0.01, risk 4.3) were significantly more common among cases than they were among controls. In addition, the plasma high-density lipoprotein cholesterol level was lower (1.00±0.09 versus 1.94±0.05 mmol/l, P<0.05) and the plasma urate level was higher (0.42±0.02 versus 0.37±0.01 mmol/l, P<0.05) in the female cases than they were in their respective controls. Low-density lipoprotein (LDL) particle sizing did not reveal an excess of small LDL particles to be a feature of CHD cases, but more than 70% both of cases and of controls had multiple LDL species. The response of the triglyceride level to a fat-rich meal was the same for CHD cases and controls. Conclusion: The population studied had a high prevalence of several risk factors for CHD, including obesity and non-insulin-dependent diabetes mellitus; however, the most prominent factor relating to CHD within the community was the presence of hypertension.

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