Risk factor for acquisition of methicilin-resistant Stapphyloccus aureus (MRSA) by trauma patients in the intensive care unit

Caroline Marshall, R. Wolfe, T. Kossmann, S. Wesselingh, G. Harrington, D. Spelman

Research output: Contribution to journalArticle

41 Citations (Scopus)

Abstract

In a previous study in the intensive care unit (ICU) of the Alfred Hospital, Melbourne, Australia, it was demonstrated that trauma patients were at particular risk of becoming colonized by methicillin-resistant Staphylococcus aureus (MRSA). We examined risk factors for MRSA acquisition in these patients using a cohort study comparing the 31 patients who acquired MRSA with 65 who did not. Data collected included ICU length of stay (LOS), mechanism of trauma, site of injury, type of surgery, trauma severity and antibiotic usage. Odds ratios (OR) were determined and adjusted for LOS. LOS in the ICU was a significant univariate predictor of MRSA acquisition (OR 13.7). When adjusted for LOS, mechanism of trauma (OR 10.4), laparotomy (OR 6.3) and administration of ticarcillin/clavulanic acid (OR 4.5) or glycopeptides (OR 5.9) remained significant. We confirmed our previous finding that LOS was associated with MRSA acquisition. Receipt of antibiotics correlated with reported literature. Novel associations were road trauma as a mechanism and laparotomy.

Original languageEnglish
Pages (from-to)245-252
Number of pages8
JournalJournal of Hospital Infection
Volume57
Issue number3
DOIs
Publication statusPublished - 1 Jul 2004

Keywords

  • Intensive care unit
  • Methicillin-resistant Staphylococcus aureus
  • Risk factor
  • Trauma

ASJC Scopus subject areas

  • Microbiology (medical)
  • Infectious Diseases

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