Abstract
Responses to non-invasive brain stimulation are highly variable between subjects. Resting state functional connectivity was investigated as a marker of plasticity induced by anodal transcranial direct current stimulation (tDCS). Twenty-six healthy adults (15 male, 26.4 ± 6.5 years) were tested. Experiment 1 investigated whether functional connectivity could predict modulation of corticospinal excitability following anodal tDCS. Experiment 2 determined test–retest reliability of connectivity measures. Three minutes of electroencephalography was recorded and connectivity was quantified with the debiased weighted phase lag index. Anodal (1 mA, 20 min) or sham tDCS was applied to the left primary motor cortex (M1), with a change in motor evoked potential amplitude recorded from the right first dorsal interosseous used as a marker of tDCS response. Connectivity in the high beta frequency (20–30 Hz) between an electrode approximating the left M1 (C3) and electrodes overlying the left parietal cortex was a strong predictor of tDCS response (cross-validated R2 = 0.69). Similar relationships were observed for alpha (8–13 Hz; R2 = 0.64), theta (4–7 Hz; R2 = 0.53), and low beta (14–19 Hz; R2 = 0.58) frequencies, however, test–retest reliability of connectivity measures was strongest for the high beta frequency model (ICC = 0.65; good reliability). Further investigation of the high beta model found that greater connectivity between C3 and a cluster of electrodes approximately overlying the left parietal cortex was associated with stronger responses to anodal (rho = 0.61, P = 0.03), but not sham tDCS (rho = 0.43, P = 0.14). Functional connectivity is a strong predictor of the neuroplastic response to tDCS and may be one important characteristic to assist targeted tDCS application.
| Language | English |
|---|---|
| Pages | 837-845 |
| Number of pages | 9 |
| Journal | European Journal of Neuroscience |
| Volume | 45 |
| Issue number | 6 |
| DOIs | |
| Publication status | Published - 1 Mar 2017 |
| Externally published | Yes |
Keywords
- electroencephalography
- motor cortex
- partial least squares
- plasticity
- transcranial magnetic stimulation
ASJC Scopus subject areas
- Neuroscience(all)
Cite this
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Resting state functional connectivity measures correlate with the response to anodal transcranial direct current stimulation. / Hordacre, Brenton; Moezzi, Bahar; Goldsworthy, Mitchell; Rogasch, Nigel; Graetz, Lynton J.; Ridding, Michael C.
In: European Journal of Neuroscience, Vol. 45, No. 6, 01.03.2017, p. 837-845.Research output: Contribution to journal › Article
TY - JOUR
T1 - Resting state functional connectivity measures correlate with the response to anodal transcranial direct current stimulation
AU - Hordacre, Brenton
AU - Moezzi, Bahar
AU - Goldsworthy, Mitchell
AU - Rogasch, Nigel
AU - Graetz, Lynton J.
AU - Ridding, Michael C.
PY - 2017/3/1
Y1 - 2017/3/1
N2 - Responses to non-invasive brain stimulation are highly variable between subjects. Resting state functional connectivity was investigated as a marker of plasticity induced by anodal transcranial direct current stimulation (tDCS). Twenty-six healthy adults (15 male, 26.4 ± 6.5 years) were tested. Experiment 1 investigated whether functional connectivity could predict modulation of corticospinal excitability following anodal tDCS. Experiment 2 determined test–retest reliability of connectivity measures. Three minutes of electroencephalography was recorded and connectivity was quantified with the debiased weighted phase lag index. Anodal (1 mA, 20 min) or sham tDCS was applied to the left primary motor cortex (M1), with a change in motor evoked potential amplitude recorded from the right first dorsal interosseous used as a marker of tDCS response. Connectivity in the high beta frequency (20–30 Hz) between an electrode approximating the left M1 (C3) and electrodes overlying the left parietal cortex was a strong predictor of tDCS response (cross-validated R2 = 0.69). Similar relationships were observed for alpha (8–13 Hz; R2 = 0.64), theta (4–7 Hz; R2 = 0.53), and low beta (14–19 Hz; R2 = 0.58) frequencies, however, test–retest reliability of connectivity measures was strongest for the high beta frequency model (ICC = 0.65; good reliability). Further investigation of the high beta model found that greater connectivity between C3 and a cluster of electrodes approximately overlying the left parietal cortex was associated with stronger responses to anodal (rho = 0.61, P = 0.03), but not sham tDCS (rho = 0.43, P = 0.14). Functional connectivity is a strong predictor of the neuroplastic response to tDCS and may be one important characteristic to assist targeted tDCS application.
AB - Responses to non-invasive brain stimulation are highly variable between subjects. Resting state functional connectivity was investigated as a marker of plasticity induced by anodal transcranial direct current stimulation (tDCS). Twenty-six healthy adults (15 male, 26.4 ± 6.5 years) were tested. Experiment 1 investigated whether functional connectivity could predict modulation of corticospinal excitability following anodal tDCS. Experiment 2 determined test–retest reliability of connectivity measures. Three minutes of electroencephalography was recorded and connectivity was quantified with the debiased weighted phase lag index. Anodal (1 mA, 20 min) or sham tDCS was applied to the left primary motor cortex (M1), with a change in motor evoked potential amplitude recorded from the right first dorsal interosseous used as a marker of tDCS response. Connectivity in the high beta frequency (20–30 Hz) between an electrode approximating the left M1 (C3) and electrodes overlying the left parietal cortex was a strong predictor of tDCS response (cross-validated R2 = 0.69). Similar relationships were observed for alpha (8–13 Hz; R2 = 0.64), theta (4–7 Hz; R2 = 0.53), and low beta (14–19 Hz; R2 = 0.58) frequencies, however, test–retest reliability of connectivity measures was strongest for the high beta frequency model (ICC = 0.65; good reliability). Further investigation of the high beta model found that greater connectivity between C3 and a cluster of electrodes approximately overlying the left parietal cortex was associated with stronger responses to anodal (rho = 0.61, P = 0.03), but not sham tDCS (rho = 0.43, P = 0.14). Functional connectivity is a strong predictor of the neuroplastic response to tDCS and may be one important characteristic to assist targeted tDCS application.
KW - electroencephalography
KW - motor cortex
KW - partial least squares
KW - plasticity
KW - transcranial magnetic stimulation
UR - http://www.scopus.com/inward/record.url?scp=85010508456&partnerID=8YFLogxK
U2 - 10.1111/ejn.13508
DO - 10.1111/ejn.13508
M3 - Article
VL - 45
SP - 837
EP - 845
JO - European Journal of Neuroscience
T2 - European Journal of Neuroscience
JF - European Journal of Neuroscience
SN - 0953-816X
IS - 6
ER -