Research and treatment approaches to depression

Ma Li Wong, Julio Licinio

Research output: Contribution to journalReview articlepeer-review

509 Citations (Scopus)


Depression is a major cause of disability worldwide, but we know little about the underlying fundamental biology. Research is hindered by the difficulties of modelling a disorder of higher cognitive functions in animals. Depression can be understood as the interaction of genetic susceptibility and environmental factors; however, current classifications are purely descriptive. The complexity of this field is best approached by rigorous explorations of known candidate systems in conjunction with the use of genomic tools to discover new targets for antidepressants and to predict therapeutic outcomes.

Original languageEnglish
Pages (from-to)343-351
Number of pages9
JournalNature Reviews Neuroscience
Issue number5
Publication statusPublished or Issued - 1 May 2001

ASJC Scopus subject areas

  • Neuroscience(all)

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