Relationship between the time interval from antenatal corticosteroid administration until preterm birth and the occurrence of respiratory morbidity

Femke F. Wilms, Jolande Y. Vis, Desiree A P M Pattinaja, Rosanna A. Kuin, Monique C. Stam, Janine M. Reuvers, Ben Willem J Mol

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Objective: The purpose of this study was to assess the relationship between neonatal respiratory morbidity and the interval between antenatal corticosteroids (ACS) administration and birth. Study Design: We performed a retrospective cohort study among women who had received ACS and delivered at <34 weeks of gestation. We categorized these women in 4 groups: ACS-to-delivery interval of 0-7, 8-14, 15-21, and 22-28 days. Multivariable logistic regression analysis assessed the association between the ACS-to-delivery interval and neonatal respiratory morbidity. Results: We included 254 neonates. Eighty-two neonates (32%) were intubated. In comparison with neonates with an ACS-to-delivery interval of 0-7 days, the risk for intubation was increased in all other groups (odds ratio [OR], 2.3; 95% confidence interval [CI], 1.15.4; OR, 5.6; 95% CI, 1.818; and OR, 4.8; 95% CI, 0.7132, not statistically significant, respectively). Conclusion: The effect of ACS decreases when the ACS-to-delivery interval exceeds 7 days. The first administration of ACS should be considered carefully.

Original languageEnglish
Pages (from-to)49.e1-49.e7
JournalAmerican Journal of Obstetrics and Gynecology
Issue number1
Publication statusPublished - 1 Jan 2011


  • corticosteroid
  • preterm delivery
  • respiratory morbidity

ASJC Scopus subject areas

  • Obstetrics and Gynaecology

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