Relationship between LDL, HDL, blood pressure and atheroma progression in the coronaries

Stephen Nicholls

Research output: Contribution to journalReview articlepeer-review

11 Citations (Scopus)


PURPOSE OF REVIEW: To highlight clinical trials that have employed coronary artery imaging to evaluate the impact of medical therapies that target established cardiovascular risk factors. RECENT FINDINGS: High resolution imaging of the entire vessel wall permits assessment of changes in the full extent of coronary atherosclerosis. Intensive lowering of LDL cholesterol and systolic blood pressure are associated with the greatest benefit in terms of slowing disease progression. Therapeutic approaches that promote the biological activity of HDL have the potential to promote regression of atherosclerotic plaque. Targeting inflammatory cascades may also have a beneficial effect on the extent and composition of coronary plaque. SUMMARY: Intensive modification of established risk factors has a profound impact on the natural history of atheroma progression.

Original languageEnglish
Pages (from-to)491-496
Number of pages6
JournalCurrent Opinion in Lipidology
Issue number6
Publication statusPublished - 1 Dec 2009


  • Atherosclerosis
  • Imaging
  • Risk factors

ASJC Scopus subject areas

  • Endocrinology, Diabetes and Metabolism
  • Molecular Biology
  • Genetics
  • Nutrition and Dietetics
  • Cardiology and Cardiovascular Medicine
  • Cell Biology

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