Regulation and Differentiation Potential of Dental Mesenchymal Stem Cells

Lei Wang, Christian Morsczeck, Stan Gronthos, Songtao Shi

Research output: Chapter in Book/Report/Conference proceedingChapterpeer-review

3 Citations (Scopus)


This chapter summarizes the regulatory factors that influence the differentiation potential of dental mesenchymal stem cells (MSCs), including dental pulp stem cells (DPSCs), stem cells from human exfoliated deciduous teeth (SHEDs), periodontal ligament stem cells (PDLSCs), dental follicle cells (DFCs), stem cells from root apical papilla (SCAPs), and gingival-derived MSCs (GMSCs). Dental MSCs can be differentiated into multiple lineages and are summarized in a table. Studies have shown that several molecules are involved in the regulation of dental MSC differentiation. This chapter also focuses on the major signaling pathways involved in the modulation of differentiation potential in dental MSCs. In conclusion, the dental MSC differentiation is regulated intensively at the cellular, molecular, and transcriptional levels.

Original languageEnglish
Title of host publicationStem Cells in Craniofacial Development and Regeneration
PublisherJohn Wiley and Sons
Number of pages12
ISBN (Print)9781118279236
Publication statusPublished or Issued - 26 Mar 2013
Externally publishedYes


  • Dental follicle cells (DFCs)
  • Dental mesenchymal stem cells (MSCs)
  • Dental pulp stem cells (DPSCs)
  • Gingival-derived MSCs
  • Periodontal ligament stem cells (PDLSCs)

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

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