Radiolabelling of TiO2 nanoparticle libraries for toxicological investigations

Anthony W. Musumeci, Lawrence R. Gahan, Tijana Rajh, Darren J. Martin, Suzanne V. Smith

Research output: Chapter in Book/Report/Conference proceedingConference contributionpeer-review

Abstract

To further our understanding of nanoparticle interactions with biological systems, it is important that highly sensitive, reliable and robust methods for labelling particles are established. We report here the application of a series of bi-functional cage ligands to radiolabel a range (i.e. shapes and sizes) of titanium dioxide (TiO2) particles. The cages were covalently attached to the surface of the particles via the use of a dopac derivative and then radiolabeled with a gamma emitting radioisotope. The final radiolabeled nanoparticles proved to be stable in solution and the method easy and robust. The application of a gamma emitter allows the radiolabeled particles to be tracked in vivo and in the environment.

Original languageEnglish
Title of host publicationBusiness and Safety Issues in the Commercialization of Nanotechnology
Pages157-162
Number of pages6
Publication statusPublished or Issued - 2010
Externally publishedYes
Event2009 MRS Fall Meeting - Boston, MA, United States
Duration: 29 Nov 20092 Dec 2009

Publication series

NameMaterials Research Society Symposium Proceedings
Volume1209
ISSN (Print)0272-9172

Conference

Conference2009 MRS Fall Meeting
CountryUnited States
CityBoston, MA
Period29/11/092/12/09

ASJC Scopus subject areas

  • Materials Science(all)
  • Condensed Matter Physics
  • Mechanics of Materials
  • Mechanical Engineering

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