Raclopride and chlorpromazine, but not clozapine, increase muscle rigidity in the rat: Relationship with D2 dopamine receptor occupancy

Kim M. Hemsley, B.app.sci., Ann D. Crocker, B.sc.

Research output: Contribution to journalArticle

15 Citations (Scopus)

Abstract

The aim of the present study was to investigate the relationship between effects on muscle tone and D2 receptor occupancy of two typical antipsychotic drugs, raclopride and chlorpromazine, and the atypical drug, clozapine. Increased muscle tone (i.e., muscle rigidity), was measured as increases in tonic electromyographic (EMG) activity of the antagonistic muscles of the rat hind limb. D2 dopamine receptor occupancy was assessed in the striatum and substantia nigra, areas involved in the regulation of muscle tone. Raclopride and chlorpromazine produced dose-dependent increases in EMG activity associated with D2 occupancy of 68%-80% in the striatum and 67%-76% in the nigra. No significant increases in EMG were observed with clozapine which showed low D2 occupancy. The results are consistent with those from human studies showing extrapyramidal side effects were associated with striatal D2 occupancy of >70%. Copyright (C) 1999 American College of Neuropsychopharmacology.

LanguageEnglish
Pages101-109
Number of pages9
JournalNeuropsychopharmacology
Volume21
Issue number1
DOIs
Publication statusPublished - Jul 1999

Keywords

  • Antipsychotic drugs
  • Dopamine receptors
  • Muscle tone
  • Rat
  • Receptor occupancy

ASJC Scopus subject areas

  • Pharmacology

Cite this

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title = "Raclopride and chlorpromazine, but not clozapine, increase muscle rigidity in the rat: Relationship with D2 dopamine receptor occupancy",
abstract = "The aim of the present study was to investigate the relationship between effects on muscle tone and D2 receptor occupancy of two typical antipsychotic drugs, raclopride and chlorpromazine, and the atypical drug, clozapine. Increased muscle tone (i.e., muscle rigidity), was measured as increases in tonic electromyographic (EMG) activity of the antagonistic muscles of the rat hind limb. D2 dopamine receptor occupancy was assessed in the striatum and substantia nigra, areas involved in the regulation of muscle tone. Raclopride and chlorpromazine produced dose-dependent increases in EMG activity associated with D2 occupancy of 68{\%}-80{\%} in the striatum and 67{\%}-76{\%} in the nigra. No significant increases in EMG were observed with clozapine which showed low D2 occupancy. The results are consistent with those from human studies showing extrapyramidal side effects were associated with striatal D2 occupancy of >70{\%}. Copyright (C) 1999 American College of Neuropsychopharmacology.",
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Raclopride and chlorpromazine, but not clozapine, increase muscle rigidity in the rat : Relationship with D2 dopamine receptor occupancy. / Hemsley, Kim M.; B.app.sci.; Crocker, Ann D.; B.sc.

In: Neuropsychopharmacology, Vol. 21, No. 1, 07.1999, p. 101-109.

Research output: Contribution to journalArticle

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