Quinine-induced hemolytic uremic syndrome

Stephen McDonald, E. M. Shanahan, A. C. Thomas, D. J. Roxby, D. Beroukas, J. A.J. Barbara

Research output: Contribution to journalArticle

24 Citations (Scopus)

Abstract

Although quinine use is very common, hemolytic uremic syndrome (HUS) following exposure to quinine is only a recently reported phenomenon, with the first description published in 1991. Previous reports have concentrated on the nature of the hematological process and in particular characterization of the quinine-induced antibodies involved. We present a case of HUS with a clear temporal and immunological relationship to quinine which demonstrates the pathognomonic renal features of HUS. An indirect antiglobulin test with the patient's serum agglutinated red blood cells only in the presence of quinine. Renal biopsy features included glomerular and arteriolar endothelial swelling, capillary loop thrombi, mesangiolysis, segmental sclerosis and segmental ischemia. Early empiric treatment with plasma exchange and corticosteroids was instituted and this resulted in recovery of renal function to normal.

LanguageEnglish
Pages397-400
Number of pages4
JournalClinical Nephrology
Volume47
Issue number6
Publication statusPublished - 9 Jul 1997

Keywords

  • Corticosteroids
  • Hemolytic uremic syndrome
  • Plasma exchange
  • Quinine

ASJC Scopus subject areas

  • Nephrology

Cite this

McDonald, S., Shanahan, E. M., Thomas, A. C., Roxby, D. J., Beroukas, D., & Barbara, J. A. J. (1997). Quinine-induced hemolytic uremic syndrome. Clinical Nephrology, 47(6), 397-400.