Pseudomonas aeruginosa: All roads lead to resistance

Elena B.M. Breidenstein, César de la Fuente-Núñez, Robert E.W. Hancock

Research output: Contribution to journalReview articlepeer-review

626 Citations (Scopus)

Abstract

Pseudomonas aeruginosa is often resistant to multiple antibiotics and consequently has joined the ranks of 'superbugs' due to its enormous capacity to engender resistance. It demonstrates decreased susceptibility to most antibiotics due to low outer membrane permeability coupled to adaptive mechanisms and can readily achieve clinical resistance. Newer research, using mutant library screens, microarray technologies and mutation frequency analysis, has identified very large collections of genes (the resistome) that when mutated lead to resistance as well as new forms of adaptive resistance that can be triggered by antibiotics themselves, in in vivo growth conditions or complex adaptations such as biofilm growth or swarming motility.

Original languageEnglish
Pages (from-to)419-426
Number of pages8
JournalTrends in Microbiology
Volume19
Issue number8
DOIs
Publication statusPublished or Issued - Aug 2011
Externally publishedYes

ASJC Scopus subject areas

  • Microbiology
  • Microbiology (medical)
  • Infectious Diseases
  • Virology

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