Proteomic characterization of mesenchymal stem cell-like populations derived from various tissue types

Krzysztof M. Mrozik, Jimin Xiong, Peter S. Zilm, Stan Gronthos, P. Mark Bartold

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

The evolution of proteomics has led to its application in identifying biomarkers of biological processes and pathways including signal transduction and cell development. Proteomic technologies are increasingly utilized to define the molecular mechanisms controlling mesenchymal stem/stromal cell (MSC) self-renewal, multipotency and fate. Bone marrow-derived MSCs are highly promising candidates in the field of regenerative medicine based on their high proliferative capacity, multilineage differentiation potential and immunomodulatory properties. Recently, equivalent MSC-like populations have also been isolated from adipose, dental and feto-maternal tissues. This chapter discusses the current technologies available for proteomic analysis and the studies performed on tissue-specific MSC-like populations to date.

Original languageEnglish
Title of host publicationStem Cells and Cancer Stem Cells, Volume 4
Subtitle of host publicationTherapeutic Applications in Disease and Injury
PublisherSpringer Netherlands
Pages267-284
Number of pages18
ISBN (Electronic)9789400728288
ISBN (Print)9789400728271
DOIs
Publication statusPublished - 1 Jan 2012

Keywords

  • Differentiation
  • Mass spectrometry
  • Mesenchymal stem cells
  • Proteomics
  • Regeneration

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Mrozik, K. M., Xiong, J., Zilm, P. S., Gronthos, S., & Bartold, P. M. (2012). Proteomic characterization of mesenchymal stem cell-like populations derived from various tissue types. In Stem Cells and Cancer Stem Cells, Volume 4: Therapeutic Applications in Disease and Injury (pp. 267-284). Springer Netherlands. https://doi.org/10.1007/978-94-007-2828-8_24