Prostaglandins and Leukotrienes

Gillian Caughey, M. J. James, L. G. Cleland

Research output: Chapter in Book/Report/Conference proceedingChapterpeer-review


Prostaglandins (PGs) and leukotrienes are lipid mediators belonging to the eicosanoid family. They are synthesized from arachidonic acid, a polyunsaturated fatty acid, via a tightly regulated pathway. A key enzyme in the synthetic pathway, cyclooxygenase, has been the target for the pharmacological modulation of PG-mediated clinical manifestations. Eicosanoids generally act as paracrine or autocrine agents and are involved in the maintenance of homeostatic processes as well as in the pathophysiology of several chronic diseases.

Original languageEnglish
Title of host publicationEncyclopedia of Human Nutrition (Third edition)
PublisherElsevier Inc.
ISBN (Electronic)9780123848857
ISBN (Print)9780123750839
Publication statusPublished or Issued - 1 Jan 2012
Externally publishedYes


  • Arachidonic acid
  • Cyclooxygenase
  • Eicosanoids
  • Leukotrienes
  • Lipoxygenase
  • Prostaglandin

ASJC Scopus subject areas

  • Medicine(all)

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