Prostaglandins and Leukotrienes

Gillian Caughey, M. J. James, L. G. Cleland

Research output: Chapter in Book/Report/Conference proceedingChapter


Prostaglandins (PGs) and leukotrienes are lipid mediators belonging to the eicosanoid family. They are synthesized from arachidonic acid, a polyunsaturated fatty acid, via a tightly regulated pathway. A key enzyme in the synthetic pathway, cyclooxygenase, has been the target for the pharmacological modulation of PG-mediated clinical manifestations. Eicosanoids generally act as paracrine or autocrine agents and are involved in the maintenance of homeostatic processes as well as in the pathophysiology of several chronic diseases.

Title of host publicationEncyclopedia of Human Nutrition (Third edition)
PublisherElsevier Inc.
Number of pages7
ISBN (Electronic)9780123848857
ISBN (Print)9780123750839
Publication statusPublished - 1 Jan 2012
Externally publishedYes


  • Arachidonic acid
  • Cyclooxygenase
  • Eicosanoids
  • Leukotrienes
  • Lipoxygenase
  • Prostaglandin

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Caughey, G., James, M. J., & Cleland, L. G. (2012). Prostaglandins and Leukotrienes. In Encyclopedia of Human Nutrition (Third edition) (Vol. 4-4, pp. 104-110). Elsevier Inc..