Prostaglandins (PGs) and leukotrienes are lipid mediators belonging to the eicosanoid family. They are synthesized from arachidonic acid, a polyunsaturated fatty acid, via a tightly regulated pathway. A key enzyme in the synthetic pathway, cyclooxygenase, has been the target for the pharmacological modulation of PG-mediated clinical manifestations. Eicosanoids generally act as paracrine or autocrine agents and are involved in the maintenance of homeostatic processes as well as in the pathophysiology of several chronic diseases.
|Title of host publication||Encyclopedia of Human Nutrition (Third edition)|
|Number of pages||7|
|Publication status||Published - 1 Jan 2012|
- Arachidonic acid
ASJC Scopus subject areas