Prospective study of flavonoid intake and risk of primary open-angle glaucoma

Jae H. Kang, Kerry Ivey, Tahani Boumenna, Bernard Rosner, Janey L. Wiggs, Louis R. Pasquale

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

Purpose: To evaluate the association between flavonoid intake and incident primary open-angle glaucoma (POAG). Methods: We followed 65 516 women from the Nurses’ Health Study (from 1984) and 42 156 men from the Health Professionals Follow-up Study (from 1986) biennially to 2012, who were 40+ years old, free of POAG, and reported eye examinations. Dietary flavonoid intake was assessed with validated repeated semi-quantitative food frequency questionnaires. Incident POAG cases (n = 1575) were confirmed with medical record review. Cohort-specific multivariable-adjusted relative risks (RRs) and 95% confidence intervals (CIs) were calculated and meta-analysed. Results: Total flavonoid intake was not associated with risk of POAG development [RR for highest (Q5: median ~645 mg/day) versus lowest quintile (Q1: ~130 mg/day) = 0.91 (95% CI = 0.77, 1.08); p for trend (p-trend) = 0.19]; the flavonoid subclasses of flavones, flavanones, polymeric flavanols or anthocyanidins were also not associated (Q5 versus Q1 comparison p-values ≥0.05 and p-trend ≥0.09). Higher intakes of flavonols and monomeric flavanols were nominally associated with lower POAG risk, based on the Q5 versus Q1 comparisons or p-trends. The Q5 versus Q1 comparison RRs were: for flavonols, 0.82 (95% CI = 0.69, 0.97; p-trend = 0.05; ~28 versus ~8 mg/day), and for monomeric flavanols, 0.86 (95% CI = 0.72, 1.02; p-trend=0.04; ~110 versus 10 mg/day). The food/beverage that contributed most to both the variation of flavonols and monomeric flavanols was tea; consuming ~2 cups/day was associated with 18% lower POAG risk (RR=0.82; 95% CI = 0.68, 0.99; p-trend = 0.02). Conclusion: Total flavonoid intake was not associated with POAG risk. Greater intakes of flavonols and monomeric flavanols and of tea showed suggestive modest associations with lower risk; these results need confirmation.

LanguageEnglish
Pagese692-e700
JournalActa Ophthalmologica
Volume96
Issue number6
DOIs
Publication statusPublished - 1 Sep 2018

Keywords

  • cohort
  • epidemiology
  • flavonoids
  • glaucoma

ASJC Scopus subject areas

  • Ophthalmology

Cite this

Kang, J. H., Ivey, K., Boumenna, T., Rosner, B., Wiggs, J. L., & Pasquale, L. R. (2018). Prospective study of flavonoid intake and risk of primary open-angle glaucoma. Acta Ophthalmologica, 96(6), e692-e700. https://doi.org/10.1111/aos.13705
Kang, Jae H. ; Ivey, Kerry ; Boumenna, Tahani ; Rosner, Bernard ; Wiggs, Janey L. ; Pasquale, Louis R. / Prospective study of flavonoid intake and risk of primary open-angle glaucoma. In: Acta Ophthalmologica. 2018 ; Vol. 96, No. 6. pp. e692-e700.
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title = "Prospective study of flavonoid intake and risk of primary open-angle glaucoma",
abstract = "Purpose: To evaluate the association between flavonoid intake and incident primary open-angle glaucoma (POAG). Methods: We followed 65 516 women from the Nurses’ Health Study (from 1984) and 42 156 men from the Health Professionals Follow-up Study (from 1986) biennially to 2012, who were 40+ years old, free of POAG, and reported eye examinations. Dietary flavonoid intake was assessed with validated repeated semi-quantitative food frequency questionnaires. Incident POAG cases (n = 1575) were confirmed with medical record review. Cohort-specific multivariable-adjusted relative risks (RRs) and 95{\%} confidence intervals (CIs) were calculated and meta-analysed. Results: Total flavonoid intake was not associated with risk of POAG development [RR for highest (Q5: median ~645 mg/day) versus lowest quintile (Q1: ~130 mg/day) = 0.91 (95{\%} CI = 0.77, 1.08); p for trend (p-trend) = 0.19]; the flavonoid subclasses of flavones, flavanones, polymeric flavanols or anthocyanidins were also not associated (Q5 versus Q1 comparison p-values ≥0.05 and p-trend ≥0.09). Higher intakes of flavonols and monomeric flavanols were nominally associated with lower POAG risk, based on the Q5 versus Q1 comparisons or p-trends. The Q5 versus Q1 comparison RRs were: for flavonols, 0.82 (95{\%} CI = 0.69, 0.97; p-trend = 0.05; ~28 versus ~8 mg/day), and for monomeric flavanols, 0.86 (95{\%} CI = 0.72, 1.02; p-trend=0.04; ~110 versus 10 mg/day). The food/beverage that contributed most to both the variation of flavonols and monomeric flavanols was tea; consuming ~2 cups/day was associated with 18{\%} lower POAG risk (RR=0.82; 95{\%} CI = 0.68, 0.99; p-trend = 0.02). Conclusion: Total flavonoid intake was not associated with POAG risk. Greater intakes of flavonols and monomeric flavanols and of tea showed suggestive modest associations with lower risk; these results need confirmation.",
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Kang, JH, Ivey, K, Boumenna, T, Rosner, B, Wiggs, JL & Pasquale, LR 2018, 'Prospective study of flavonoid intake and risk of primary open-angle glaucoma', Acta Ophthalmologica, vol. 96, no. 6, pp. e692-e700. https://doi.org/10.1111/aos.13705

Prospective study of flavonoid intake and risk of primary open-angle glaucoma. / Kang, Jae H.; Ivey, Kerry; Boumenna, Tahani; Rosner, Bernard; Wiggs, Janey L.; Pasquale, Louis R.

In: Acta Ophthalmologica, Vol. 96, No. 6, 01.09.2018, p. e692-e700.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Prospective study of flavonoid intake and risk of primary open-angle glaucoma

AU - Kang, Jae H.

AU - Ivey, Kerry

AU - Boumenna, Tahani

AU - Rosner, Bernard

AU - Wiggs, Janey L.

AU - Pasquale, Louis R.

PY - 2018/9/1

Y1 - 2018/9/1

N2 - Purpose: To evaluate the association between flavonoid intake and incident primary open-angle glaucoma (POAG). Methods: We followed 65 516 women from the Nurses’ Health Study (from 1984) and 42 156 men from the Health Professionals Follow-up Study (from 1986) biennially to 2012, who were 40+ years old, free of POAG, and reported eye examinations. Dietary flavonoid intake was assessed with validated repeated semi-quantitative food frequency questionnaires. Incident POAG cases (n = 1575) were confirmed with medical record review. Cohort-specific multivariable-adjusted relative risks (RRs) and 95% confidence intervals (CIs) were calculated and meta-analysed. Results: Total flavonoid intake was not associated with risk of POAG development [RR for highest (Q5: median ~645 mg/day) versus lowest quintile (Q1: ~130 mg/day) = 0.91 (95% CI = 0.77, 1.08); p for trend (p-trend) = 0.19]; the flavonoid subclasses of flavones, flavanones, polymeric flavanols or anthocyanidins were also not associated (Q5 versus Q1 comparison p-values ≥0.05 and p-trend ≥0.09). Higher intakes of flavonols and monomeric flavanols were nominally associated with lower POAG risk, based on the Q5 versus Q1 comparisons or p-trends. The Q5 versus Q1 comparison RRs were: for flavonols, 0.82 (95% CI = 0.69, 0.97; p-trend = 0.05; ~28 versus ~8 mg/day), and for monomeric flavanols, 0.86 (95% CI = 0.72, 1.02; p-trend=0.04; ~110 versus 10 mg/day). The food/beverage that contributed most to both the variation of flavonols and monomeric flavanols was tea; consuming ~2 cups/day was associated with 18% lower POAG risk (RR=0.82; 95% CI = 0.68, 0.99; p-trend = 0.02). Conclusion: Total flavonoid intake was not associated with POAG risk. Greater intakes of flavonols and monomeric flavanols and of tea showed suggestive modest associations with lower risk; these results need confirmation.

AB - Purpose: To evaluate the association between flavonoid intake and incident primary open-angle glaucoma (POAG). Methods: We followed 65 516 women from the Nurses’ Health Study (from 1984) and 42 156 men from the Health Professionals Follow-up Study (from 1986) biennially to 2012, who were 40+ years old, free of POAG, and reported eye examinations. Dietary flavonoid intake was assessed with validated repeated semi-quantitative food frequency questionnaires. Incident POAG cases (n = 1575) were confirmed with medical record review. Cohort-specific multivariable-adjusted relative risks (RRs) and 95% confidence intervals (CIs) were calculated and meta-analysed. Results: Total flavonoid intake was not associated with risk of POAG development [RR for highest (Q5: median ~645 mg/day) versus lowest quintile (Q1: ~130 mg/day) = 0.91 (95% CI = 0.77, 1.08); p for trend (p-trend) = 0.19]; the flavonoid subclasses of flavones, flavanones, polymeric flavanols or anthocyanidins were also not associated (Q5 versus Q1 comparison p-values ≥0.05 and p-trend ≥0.09). Higher intakes of flavonols and monomeric flavanols were nominally associated with lower POAG risk, based on the Q5 versus Q1 comparisons or p-trends. The Q5 versus Q1 comparison RRs were: for flavonols, 0.82 (95% CI = 0.69, 0.97; p-trend = 0.05; ~28 versus ~8 mg/day), and for monomeric flavanols, 0.86 (95% CI = 0.72, 1.02; p-trend=0.04; ~110 versus 10 mg/day). The food/beverage that contributed most to both the variation of flavonols and monomeric flavanols was tea; consuming ~2 cups/day was associated with 18% lower POAG risk (RR=0.82; 95% CI = 0.68, 0.99; p-trend = 0.02). Conclusion: Total flavonoid intake was not associated with POAG risk. Greater intakes of flavonols and monomeric flavanols and of tea showed suggestive modest associations with lower risk; these results need confirmation.

KW - cohort

KW - epidemiology

KW - flavonoids

KW - glaucoma

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U2 - 10.1111/aos.13705

DO - 10.1111/aos.13705

M3 - Article

VL - 96

SP - e692-e700

JO - Acta Ophthalmologica

T2 - Acta Ophthalmologica

JF - Acta Ophthalmologica

SN - 1755-375X

IS - 6

ER -