Preventing Preterm Birth with Progesterone in Women with a Short Cervical Length from a Low-Risk Population: A Multicenter Double-Blind Placebo-Controlled Randomized Trial

Melanie A. Van Os, A. Jeanine Van Der Ven, C. Emily Kleinrouweler, Ewoud Schuit, Brenda M. Kazemier, Corine J. Verhoeven, Esteriek De Miranda, Aleid G. Van Wassenaer-Leemhuis, J. Marko Sikkema, Mallory D. Woiski, Patrick M. Bossuyt, Eva Pajkrt, Christianne J M De Groot, Ben Willem J Mol, Monique C. Haak

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16 Citations (Scopus)

Abstract

Objective The objective of this study was to evaluate the effectiveness of vaginal progesterone in reducing adverse neonatal outcome due to preterm birth (PTB) in low-risk pregnant women with a short cervical length (CL). Study Design Women with a singleton pregnancy without a history of PTB underwent CL measurement at 18 to 22 weeks. Women with a CL ≤ 30 mm received vaginal progesterone or placebo. Primary outcome was adverse neonatal outcome, defined as a composite of respiratory distress syndrome, bronchopulmonary dysplasia, intracerebral hemorrhage > grade II, necrotizing enterocolitis > stage 1, proven sepsis, or death before discharge. Secondary outcomes included time to delivery, PTB before 32, 34, and 37 weeks of gestation. Analysis was by intention to treat.

LanguageEnglish
Pages993-1000
Number of pages8
JournalAmerican Journal of Perinatology
Volume32
Issue number10
DOIs
Publication statusPublished - 4 Mar 2015

Keywords

  • cervical length
  • neonatal outcome
  • preterm birth
  • progesterone

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Obstetrics and Gynaecology

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