Preventing Preterm Birth with Progesterone in Women with a Short Cervical Length from a Low-Risk Population: A Multicenter Double-Blind Placebo-Controlled Randomized Trial

Melanie A. Van Os, A. Jeanine Van Der Ven, C. Emily Kleinrouweler, Ewoud Schuit, Brenda M. Kazemier, Corine J. Verhoeven, Esteriek De Miranda, Aleid G. Van Wassenaer-Leemhuis, J. Marko Sikkema, Mallory D. Woiski, Patrick M. Bossuyt, Eva Pajkrt, Christianne J M De Groot, Ben Willem J Mol, Monique C. Haak

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22 Citations (Scopus)


Objective The objective of this study was to evaluate the effectiveness of vaginal progesterone in reducing adverse neonatal outcome due to preterm birth (PTB) in low-risk pregnant women with a short cervical length (CL). Study Design Women with a singleton pregnancy without a history of PTB underwent CL measurement at 18 to 22 weeks. Women with a CL ≤ 30 mm received vaginal progesterone or placebo. Primary outcome was adverse neonatal outcome, defined as a composite of respiratory distress syndrome, bronchopulmonary dysplasia, intracerebral hemorrhage > grade II, necrotizing enterocolitis > stage 1, proven sepsis, or death before discharge. Secondary outcomes included time to delivery, PTB before 32, 34, and 37 weeks of gestation. Analysis was by intention to treat.

Original languageEnglish
Pages (from-to)993-1000
Number of pages8
JournalAmerican Journal of Perinatology
Issue number10
Publication statusPublished or Issued - 4 Mar 2015


  • cervical length
  • neonatal outcome
  • preterm birth
  • progesterone

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Obstetrics and Gynaecology

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