Prevalence of genetic renal disease in children

Jeffery Fletcher, Stephen McDonald, Stephen I. Alexander

Research output: Contribution to journalArticle

25 Citations (Scopus)

Abstract

Background: Genetic etiology comprises a significant proportion of renal disease in childhood. Completion of the Human Genome Project and increased genetic testing has assisted with the increased recognition of a genetic basis to many renal disorders. Australia and New Zealand have a relatively stable but diverse population, with eight major pediatric nephrology referral centers, which allow ascertainment of disease frequency. Methods: To determine prevalence, pediatric nephrologists at the eight centers in Australia and New Zealand were surveyed on their estimated number of patients with renal disease of genetic etiology over a 10-year period. Disease prevalence was calculated using combined national population data. Results: The overall prevalence of genetic kidney disease in children in Australia and New Zealand is 70.6 children per million age-representative population. Congenital anomalies of the kidney and urinary tract (CAKUT) and steroid-resistant nephrotic syndrome (SRNS) are the most frequent, with a prevalence of 16.3 and 10.7, respectively, per million children. Conclusion: We find a similar prevalence of genetic renal disorders in Australia and New Zealand to those reported in other countries. This is likely to be due to inclusion of children with all forms of renal disease rather than being limited to those with renal impairment.

LanguageEnglish
Pages251-256
Number of pages6
JournalPediatric Nephrology
Volume28
Issue number2
DOIs
Publication statusPublished - 1 Feb 2013

Keywords

  • CAKUT
  • ESRD
  • Genetic kidney disease
  • Genetics
  • Pediatrics
  • Prevalence

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Nephrology

Cite this

Fletcher, Jeffery ; McDonald, Stephen ; Alexander, Stephen I. / Prevalence of genetic renal disease in children. In: Pediatric Nephrology. 2013 ; Vol. 28, No. 2. pp. 251-256.
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Prevalence of genetic renal disease in children. / Fletcher, Jeffery; McDonald, Stephen; Alexander, Stephen I.

In: Pediatric Nephrology, Vol. 28, No. 2, 01.02.2013, p. 251-256.

Research output: Contribution to journalArticle

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