Predisposition for venoconstriction in the equine laminar dermis: Implications in equine laminitis

John F. Peroni, James N. Moore, Erik Noschka, Megan E. Grafton, Maria Aceves-Avila, Stephen J. Lewis, Tom P. Robertson

Research output: Contribution to journalArticle

52 Citations (Scopus)

Abstract

Equine laminitis is a crippling condition associated with a variety of systemic diseases. Although it is apparent that the prodromal stages of laminitis involve microvascular dysfunction, little is known regarding the physiology of this vasculature. The aim of the present study was to determine the relative responses of equine laminar arteries and veins to the vasoconstrictor agonists phenylephrine (1 nM-10 μM), 5-HT (1 nM-10 μM), PGF (1 nM-100 μM), and endothelin-1 (1 pM-1 μM). We have determined that laminar veins were more sensitive, with respect to the concentration of agonist required to initiate a contractile response and to achieve EC50, for all agonists tested. EC50 values, for veins and arteries, respectively, were 84 ± 7 vs. 688 ± 42 nM for phenylephrine, 35 ± 6 vs. 224 ± 13 nM for 5-HT, 496 ± 43 nM vs. 3.0 ± 0.6 μM for PGF, and 467 ± 38 pM vs. 70.6 ± 6.4 nM for endothelin-1. Moreover, when expressed as a percentage of the response to a depolarizing stimulus (80 mM potassium), the maximal contractile response of laminar veins exceeded that for the laminar arteries for each agonist. These results indicate that there may be a predisposition for venoconstriction within the vasculature of the equine digit. While this physiological predisposition for venoconstriction may be important in the regulation of blood flow during exercise, it also may help to explain why laminitis can result from a variety of pathological systemic conditions.

Original languageEnglish
Pages (from-to)759-763
Number of pages5
JournalJournal of Applied Physiology
Volume100
Issue number3
DOIs
Publication statusPublished - 1 Mar 2006
Externally publishedYes

Keywords

  • Equine laminar arteries
  • Veins

ASJC Scopus subject areas

  • Physiology
  • Physiology (medical)

Cite this

Peroni, J. F., Moore, J. N., Noschka, E., Grafton, M. E., Aceves-Avila, M., Lewis, S. J., & Robertson, T. P. (2006). Predisposition for venoconstriction in the equine laminar dermis: Implications in equine laminitis. Journal of Applied Physiology, 100(3), 759-763. https://doi.org/10.1152/japplphysiol.00794.2005