Predictors of Baseline Peritoneal Transport Status in Australian and New Zealand Peritoneal Dialysis Patients

Markus Rumpsfeld, Stephen McDonald, David M. Purdie, John Collins, David W. Johnson

Research output: Contribution to journalArticle

62 Citations (Scopus)

Abstract

Background: Factors that predict peritoneal transport status in peritoneal dialysis (PD) patients are poorly understood. The aim of the present study is to determine these factors in Australian and New Zealand incident PD patients. Methods: The study included all patients on the Australian and New Zealand Dialysis and Transplant Registry who started PD therapy between April 1, 1991, and March 31, 2002, and underwent a peritoneal equilibration test (PET) within the first 6 months. Predictors of peritoneal transport category and dialysate-plasma creatinine ratio at 4 hours (D-P Cr 4h) were assessed by multivariate ordinal logistic regression and multiple linear regression, respectively. Results: A total of 3,188 patients were studied. Mean D-P Cr 4h was 0.69 ± 0.13. High transport status was associated with older age (adjusted odds ratio [OR], 1.08 for each 10 years; 95% confidence interval [CI], 1.03 to 1.13), Maori and Pacific Islander racial origin (OR, 1.48; 95% CI, 1. 13 to 1.94), and normal body mass index (BMI; < 18.5 kg/m2: OR, 0.90; 95% CI, 0.65 to 1.24; BMI of 18.5 to 25 kg/m2: OR, 1 [reference]; BMI of 25 to 30 kg/m2: OR, 0.81; 95% CI, 0.70 to 0.95; BMI > 30 kg/m2: OR, 0.71; 95% CI, 0.58 to 0.86), but was not independently predicted by sex, diabetes, other comorbid diseases, smoking, previous hemodialysis therapy or transplantation, or residual renal function. Similar results were found when peritoneal permeability was modeled as a continuous variable (D-P Cr 4h). Conclusion: In Australian and New Zealand PD patients, higher peritoneal transport status is independently associated with racial origin, older age, and lower BMI. The diversity of peritoneal transport characteristics in different ethnic populations suggests that additional validation of PET measurements in various racial groups and study of their relationship to patient outcomes are warranted.

Original languageEnglish
Pages (from-to)492-501
Number of pages10
JournalAmerican Journal of Kidney Diseases
Volume43
Issue number3
DOIs
Publication statusPublished - 2004
Externally publishedYes

Keywords

  • Age
  • Body mass index (BMI)
  • Body size
  • High transporter
  • Peritoneal dialysis (PD)
  • Peritoneal permeability
  • Solute transport

ASJC Scopus subject areas

  • Nephrology

Cite this