Prediction of recurrent and residual cervical dysplasia by human papillomavirus detection among patients with abnormal cytology

Liesbeth J M Bollen, Steven P. Tjong-A-Hung, Jacobus Van Der Velden, Ben Willem Mol, Fiebo W J Ten Kate, Jan Ter Schegget, Otto P. Bleker

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Abstract

To determine the discriminative capacity of human papillomavirus (HPV) DNA testing for recurrent and residual cervical dysplasia, 43 patients with abnormal cytology after treatment for cervical dysplasia were tested for the presence of HPV DNA by PCR. An endocervical curettage was performed in all patients for histological examination. Sixteen of the 43 patients showed moderate or severe dysplasia. The HPV test was positive in all 16 patients with recurrent or residual dysplasia and negative in 12 of the 27 patients without dysplasia. The sensitivity and specificity of the HPV test were 100 and 44%, respectively. The likelihood ratio of a positive HPV test was 1.8, whereas a negative HPV test had a likelihood ratio of 0.12. Testing for the presence of HPV has the potential to select patients without recurrent or residual cervical dysplasia who have an abnormal cytological smear. This may have clinical implications, since unnecessary diagnostic conizations may be avoided in patients with abnormal cytology after treatment for cervical dysplasia and a negative HPV test.

Original languageEnglish
Pages (from-to)199-201
Number of pages3
JournalGynecologic Oncology
Volume72
Issue number2
DOIs
Publication statusPublished - 1 Jan 1999

ASJC Scopus subject areas

  • Oncology
  • Obstetrics and Gynaecology

Cite this

Bollen, L. J. M., Tjong-A-Hung, S. P., Van Der Velden, J., Mol, B. W., Ten Kate, F. W. J., Ter Schegget, J., & Bleker, O. P. (1999). Prediction of recurrent and residual cervical dysplasia by human papillomavirus detection among patients with abnormal cytology. Gynecologic Oncology, 72(2), 199-201. https://doi.org/10.1006/gyno.1998.5250