Predicting lead relative bioavailability in peri-urban contaminated soils using in vitro bioaccessibility assays

Albert L. Juhasz, Euan Smith, John Weber, Matthew Rees, Tim Kuchel, Allan Rofe, Lloyd Sansom, Ravi Naidu

Research output: Contribution to journalArticle

25 Citations (Scopus)


In this study, lead (Pb) bioaccessibility was assessed in peri-urban contaminated soils using a variety of established in vitro assays. Bioaccessibility data was then used to predict Pb relative bioavailability (RBA) using published in vivo-in vitro regression models in order to compare calculated estimates and measured values. Lead bioaccessibility varied depending on the in vitro methodology employed with the relative bioavailability leaching procedure (RBALP) and in vitro gastrointestinal (IVG) assays providing more conservative Pb bioaccessibility values compared to those determined using PBET, UBM and Rel-SBRC-I assays. When Pb RBA was calculated, predicted values using PBET-G and UBM-G data were similar to measured Pb RBA values. However, Pb RBA was over-estimated by 1.6-5.5- and 2.6-6.6-fold when data and regression models from RBALP and IVG-G assays were employed.

Original languageEnglish
Pages (from-to)604-611
Number of pages8
JournalJournal of Environmental Science and Health - Part A Toxic/Hazardous Substances and Environmental Engineering
Issue number6
Publication statusPublished - 11 Mar 2013


  • Bioaccessibility
  • in vitro
  • in vivo
  • lead
  • relative bioavailability

ASJC Scopus subject areas

  • Environmental Engineering

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