Potential role of increased matrix metalloproteinase-2 (MMP2) transcription in impaired adipogenesis in type 2 diabetes mellitus

Severine G. Dubois, Yourka D. Tchoukalova, Leonie Heilbronn, Jeanine B. Albu, David E. Kelley, Steven R. Smith, Xiaobing Fang, Eric Ravussin

Research output: Contribution to journalArticle

11 Citations (Scopus)

Abstract

We measured gene expression of paracrine regulators involved in adipocyte differentiation within the stromovascular fraction of abdominal subcutaneous adipose tissue from obese individuals with (n = 30) and without (n = 18) type 2 diabetes mellitus (T2DM). Despite similar adiposity by design, subjects with T2DM had larger adipocytes (0.92 ± 0.28 vs. 0.75 ± 0.17 μl, p < 0.05) than controls. Gene expression of the adipogenic marker aP2 was lower (0.35 ± 0.16 vs. 0.58 ± 0.27 arbitrary units, p < 0.05) whereas the expression of matricellular peptidase, MMP2 was higher (1.65 ± 0.17 vs. 1.27 ± 0.21, p = 0.02) in T2DM vs. controls. The gene expression levels between the aP2 and MMP2 were inversely correlated (r = -0.32, p = 0.03). We conclude that early steps of adipogenesis may be impaired in T2DM independently of obesity due, in part, to an upregulation of the MMP2 transcription.

LanguageEnglish
Pages725-728
Number of pages4
JournalBiochemical and Biophysical Research Communications
Volume367
Issue number4
DOIs
Publication statusPublished - 21 Mar 2008
Externally publishedYes

Keywords

  • Adipocyte
  • Fatty acid binding protein aP2
  • Matrix metalloproteinase
  • Obesity
  • Type 2 diabetes

ASJC Scopus subject areas

  • Biophysics
  • Biochemistry
  • Molecular Biology
  • Cell Biology

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