Postural tachycardia syndrome: Current perspectives

Rachel Wells, Andrew J. Spurrier, Dominik Linz, Celine Gallagher, Rajiv Mahajan, Prash Sanders, Amanda Page, Dennis H. Lau

Research output: Contribution to journalReview article

4 Citations (Scopus)

Abstract

Postural tachycardia syndrome (POTS) is the combination of an exaggerated heart rate response to standing, in association with symptoms of lightheadedness or pre-syncope that improve when recumbent. The condition is often associated with fatigue and brain fog, resulting in significant disruptions at a critical time of diagnosis in adolescence and young adulthood. The heterogeneity of the underlying pathophysiology and the variable response to therapeutic interventions make management of this condition challenging for both patients and physicians alike. Here, we aim to review the factors and mechanisms that may contribute to the symptoms and signs of POTS and to present our perspectives on the clinical approach toward the diagnosis and management of this complex syndrome.

LanguageEnglish
Pages1-11
Number of pages11
JournalVascular Health and Risk Management
Volume14
DOIs
Publication statusPublished - 29 Dec 2018

Keywords

  • Autonomic
  • Baroreflex
  • Doppler
  • Hypermobility
  • Orthostatic

ASJC Scopus subject areas

  • Endocrinology, Diabetes and Metabolism
  • Hematology
  • Public Health, Environmental and Occupational Health
  • Cardiology and Cardiovascular Medicine
  • Pharmacology (medical)

Cite this

Wells, R., Spurrier, A. J., Linz, D., Gallagher, C., Mahajan, R., Sanders, P., ... Lau, D. H. (2018). Postural tachycardia syndrome: Current perspectives. Vascular Health and Risk Management, 14, 1-11. https://doi.org/10.2147/VHRM.S127393
Wells, Rachel ; Spurrier, Andrew J. ; Linz, Dominik ; Gallagher, Celine ; Mahajan, Rajiv ; Sanders, Prash ; Page, Amanda ; Lau, Dennis H. / Postural tachycardia syndrome : Current perspectives. In: Vascular Health and Risk Management. 2018 ; Vol. 14. pp. 1-11.
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Wells, R, Spurrier, AJ, Linz, D, Gallagher, C, Mahajan, R, Sanders, P, Page, A & Lau, DH 2018, 'Postural tachycardia syndrome: Current perspectives', Vascular Health and Risk Management, vol. 14, pp. 1-11. https://doi.org/10.2147/VHRM.S127393

Postural tachycardia syndrome : Current perspectives. / Wells, Rachel; Spurrier, Andrew J.; Linz, Dominik; Gallagher, Celine; Mahajan, Rajiv; Sanders, Prash; Page, Amanda; Lau, Dennis H.

In: Vascular Health and Risk Management, Vol. 14, 29.12.2018, p. 1-11.

Research output: Contribution to journalReview article

TY - JOUR

T1 - Postural tachycardia syndrome

T2 - Vascular Health and Risk Management

AU - Wells, Rachel

AU - Spurrier, Andrew J.

AU - Linz, Dominik

AU - Gallagher, Celine

AU - Mahajan, Rajiv

AU - Sanders, Prash

AU - Page, Amanda

AU - Lau, Dennis H.

PY - 2018/12/29

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N2 - Postural tachycardia syndrome (POTS) is the combination of an exaggerated heart rate response to standing, in association with symptoms of lightheadedness or pre-syncope that improve when recumbent. The condition is often associated with fatigue and brain fog, resulting in significant disruptions at a critical time of diagnosis in adolescence and young adulthood. The heterogeneity of the underlying pathophysiology and the variable response to therapeutic interventions make management of this condition challenging for both patients and physicians alike. Here, we aim to review the factors and mechanisms that may contribute to the symptoms and signs of POTS and to present our perspectives on the clinical approach toward the diagnosis and management of this complex syndrome.

AB - Postural tachycardia syndrome (POTS) is the combination of an exaggerated heart rate response to standing, in association with symptoms of lightheadedness or pre-syncope that improve when recumbent. The condition is often associated with fatigue and brain fog, resulting in significant disruptions at a critical time of diagnosis in adolescence and young adulthood. The heterogeneity of the underlying pathophysiology and the variable response to therapeutic interventions make management of this condition challenging for both patients and physicians alike. Here, we aim to review the factors and mechanisms that may contribute to the symptoms and signs of POTS and to present our perspectives on the clinical approach toward the diagnosis and management of this complex syndrome.

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KW - Baroreflex

KW - Doppler

KW - Hypermobility

KW - Orthostatic

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Wells R, Spurrier AJ, Linz D, Gallagher C, Mahajan R, Sanders P et al. Postural tachycardia syndrome: Current perspectives. Vascular Health and Risk Management. 2018 Dec 29;14:1-11. https://doi.org/10.2147/VHRM.S127393